Evidence map›Paper›PMID 35689251›Full record

ArticleJournal of cannabis research2022

A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function.

Carol J Milligan, Lyndsey L Anderson, Michael T Bowen, Samuel D Banister, Iain S McGregor, Jonathon C Arnold, Steven Petrou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cannabis research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. The Pharmacological Profile of Plant-Derived Cannabinoids In Vitro.Current topics in behavioral neurosciences · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Cannabidiol inhibits NaNature communications · 2023
    Article
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carol J MilliganFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia. carol.milligan@florey.edu.au.ORCID http://orcid.org/0000-0003-0353-7228
Lyndsey L AndersonBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Michael T BowenBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Samuel D BanisterBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Iain S McGregorBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Jonathon C ArnoldBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Steven PetrouFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, 3010, Australia.
The University of Sydney · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPurified cannabidiol (CBD), a non-psychoactive phytocannabinoid, has gained regulatory approval to treat intractable childhood epilepsies. Despite this, artisanal and commercial CBD-dominant hemp-based products continue to be used by epilepsy patients. Notably, the CBD doses used in these latter products are much lower than that found to be effective in reducing seizures in clinical trials with purified CBD. This might be because these CBD-dominant hemp products contain other bioactive compounds, including phytocannabinoids and terpenes, which may exert unique effects on epilepsy-relevant drug targets. Voltage-gated sodium (Na

methodsUsing automated-planar patch-clamp technology, we profile a hemp-derived nutraceutical product (NP) against human Na

resultsNP modifies peak current amplitude of the Na

conclusionsThis CBD-dominant NP potently inhibits Na

Indexed as

CannabidiolEntourage effectHemp seed oilPhytocannabinoidsTerpenesVoltage-gated sodium channels

Identifiers

PMID35689251
PMCPMC9185959
OpenAlexW4281830903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.