ArticleBMC geriatrics2022
Low physical activity is the strongest factor associated with frailty phenotype and frailty index: data from baseline phase of Birjand Longitudinal Aging Study (BLAS).
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Risk factors for frailty in older adults with cancer: a systematic review.BMC geriatrics · 2026Pooled it
- Swedish massage versus hip strengthening exercises for pain and function in older adults with knee osteoarthritis: a randomized controlled trial.Aging clinical and experimental research · 2026Trial
- Gender differences in the association between physical frailty and cognitive function among older adults: A cross-sectional study in rural Guizhou, China.Scientific reports · 2026Article
- Development and validation of the Frailty Questionnaire-5 (FQ-5), a PRISMA-7-derived screening tool for frailty: a diagnostic accuracy study in primary care.BMC geriatrics · 2026Article
- Article
- Joint trajectories of objective physical function and cognition and risk of incident dementia: a population-based cohort study.Frontiers in psychiatry · 2026Article
- Medication Use by Older Adults with Frailty: A Scoping Review.Pharmacy (Basel, Switzerland) · 2025Review
- The association of the SIRT6 rs117385980 variant with frailty and longevity: an exploratory study.Scientific reports · 2025Article
- Association of physical activity levels with frailty index in elderly Chinese: evidence from the China health and retirement longitudinal study (CHARLS).BMC geriatrics · 2025Observational
- Associations between dimensions of physical activity (intensity, frequency, duration, and volume) and frailty among middle-aged and older Chinese adults.Journal of exercise science and fitness · 2025Article
- The Role of Physical Activity and Exercise in Enhancing Resilience and Delaying Frailty in Saudi Arabia.Healthcare (Basel, Switzerland) · 2025Article
- Association of dietary health indices with frailty.BMC public health · 2025Article
- Observational
- Dynapenia-abdominal obesity and mortality risk, is independent effect obscured by age and frailty?:Birjand Longitudinal Aging Study (BLAS).Journal of diabetes and metabolic disorders · 2024Article
- Article
- Effect of leisure activity on frailty trajectories among Chinese older adults: a 16-year longitudinal study.BMC geriatrics · 2024Article
- Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review.Aging and disease · 2024Review
- Factors Associated with Frailty in Older Adults in Community and Nursing Home Settings: A Systematic Review with a Meta-Analysis.Journal of clinical medicine · 2024Review
- The bidirectional relationship between activities of daily living and frailty during short-and long-term follow-up period among the middle-aged and older population: findings from the Chinese nationwide cohort study.Frontiers in public health · 2024Article
- The relationship between health behaviors and quality of life: the mediating roles of activities of daily living and psychological distress.Frontiers in public health · 2024Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty is the most complicated expression of aging that is related to disability or multi-morbidity. The aim of the present study was to estimate the prevalence of frailty and its associated factors among community-dwelling aged population.
methodsA total of 1529 eligible community- dwelling older adults (≥ 60 years) were enrolled in the baseline phase of Birjand Longitudinal Aging Study (BLAS) from 2019 to 2020. Their frailty status was assessed using the Fried's frailty phenotype and frailty index. Sociodemographic factors, including sex, age, marital status, and education level, were collected. Health status assessment included the history of hypertension, diabetes mellitus, cardiovascular disease, Alzheimer's diseases and dementia, and other health conditions. Furthermore, functional assessment (ADL, IADL) and anthropometric measurements including height, weight, waist, calf, and mid-arm circumference were made and the body mass index was calculated. The nutrition status and polypharmacy (use 3 or more medication) were also evaluated.
resultsThe prevalence of frailty was 21.69% according to the frailty phenotype and 23.97% according to the frailty index. A multiple logistic regression model showed a strong association between low physical activity and frailty phenotype (OR = 36.31, CI = 16.99-77.56, P < 0.01), and frailty index (OR = 15.46, CI = 5.65-42.34, P < 0.01). Other factors like old age (≥80), female sex, malnutrition, polypharmacy, obesity, and arthritis were also associated with frailty. The Kappa coefficient of the agreement between these two instruments was 0.18.
conclusionIt seems that low physical activity is the most important determinant of frailty. Low physical activity and some other factors may be preventable or modifiable and thus serve as clinically relevant targets for intervention.
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