Evidence map›Paper›PMID 35689150›Full record

ArticleMikrochimica acta2022

Maltose-functional metal-organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination.

Wen Ma, Bingxin Yang, Jun Li, Mingxia Liu, Xianjiang Li, Huwei Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Wen MaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. wen.ma@bjmu.edu.cn.ORCID http://orcid.org/0000-0001-5140-4564
Bingxin YangKey Laboratory of Chemical Metrology and Applications On Nutrition and Health for State Market Regulation, Division of Metrology in Chemistry, National Institute of Metrology, Beijing, 100029, China.
Jun LiState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Mingxia LiuThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Xianjiang LiKey Laboratory of Chemical Metrology and Applications On Nutrition and Health for State Market Regulation, Division of Metrology in Chemistry, National Institute of Metrology, Beijing, 100029, China. lixianjiang@nim.ac.cn.ORCID http://orcid.org/0000-0003-0310-0376
Huwei LiuBeijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.ORCID http://orcid.org/0000-0001-6540-9657
National Institute of Metrology · CNPeking University · CNCapital Medical University · CNChina Pharmaceutical University · CN

Funding

Beijing Key Laboratory of Mental Disorders 2021JSJB02National Natural Science Foundation of China 21804123National Natural Science Foundation of China 22004004
6 · The paper itself

Abstract

A series of functional metal-organic frameworks (MOFs) were facilely prepared through an one-pot procedure or post-synthetic modification strategy and used as matrices in laser desorption ionization mass spectrometry (LDI-MS). Compared with traditional organic matrices and other MOFs, maltose-functional MOF MIL-101-maltose demonstrated ultrahigh ionization efficiency, free matrix background, uniform crystallization, and good dispersibility. A simple, general, and efficient LDI-MS platform was developed for rapid detection of various small biomolecules using MIL-101-maltose as matrix, providing several advantages including low sample consumption of 500 nL, short analysis time of few seconds, strong salt tolerance (500 mM NaCl), and satisfactory reproducibility. The MIL-101-maltose matrix was used for serum glucose determination and successfully distinguished the diabetic patients from the healthy controls. This work provides a generic LDI-MS platform for fast determination of small biomolecules with high potential in clinical diagnosis and disease monitoring.

Indexed as

Metal-Organic FrameworksHumansLasersMaltoseReproducibility of ResultsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationMaltoseMetal-Organic FrameworksBiomolecule determinationClinical diagnosisGlucose monitoringLaser desorption ionization mass spectrometryMetal–organic framework

Identifiers

PMID35689150
OpenAlexW4282942353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.