Evidence map›Paper›PMID 35689105›Full record

Observational studyWorld journal of urology2022

Antibiotic prophylaxis in patients who had undergone to prostate biopsy in between the EMA warning era: effects of fluoroquinolones in diabetic and non-diabetic patients. Results of an observational cohort study.

Riccardo Bartoletti, Francesco Claps, Gabriele Tulone, Alessandro Perotti, Alessandro Zucchi, Niccolò Riccardi, Vincenzo Ficarra, Cosimo De Nunzio, Andrea Tubaro, Alchiede Simonato

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Riccardo BartolettiDepartment of Translational Research a New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. riccardo.bartoletti@unipi.it.ORCID http://orcid.org/0000-0002-0021-0302
Francesco ClapsDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Gabriele TuloneDepartment of Surgical, Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy.
Alessandro PerottiDepartment of Translational Research a New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Alessandro ZucchiDepartment of Translational Research a New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Niccolò RiccardiInfectivology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
Vincenzo FicarraDepartment of Surgery, University of Messina, Messina, Italy.
Cosimo De NunzioDepartment. of Urology, University Rome La Sapienza, Rome, Italy.
Andrea TubaroDepartment. of Urology, University Rome La Sapienza, Rome, Italy.
Alchiede SimonatoDepartment of Surgical, Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy.
University of Pisa · ITSapienza University of Rome · ITUniversity of Palermo · ITAzienda Ospedaliera Universitaria Pisana · ITUniversity of Messina · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the effects of different antibiotic prophylaxis regimens in patients with diabetes mellitus (DM) candidates to trans-rectal ultrasound-guided prostate biopsy (TRUSPB).

methods143 outpatients with DM who underwent TRUSPB during the period 2018-2020 were selected from a cohort of 1150 patients in 3 different institutions. Exclusion criteria were allergies, concomitant anti-platelet therapies and uncontrolled DM. Different antibiotic prophylaxis regimens were adopted. Bacterial resistance levels to fluoroquinolones into the different communities were also collected. Univariable and multivariable binomial logistic regression analyses were used to assess the odds ratio (OR) with 95% confidence intervals (CIs) testing the risk of infective complications' occurrence after adjusting for clinical covariates.

resultsOverall, DM patients were significantly associated with infective complications' occurrence (p < 0.001). No differences on the event of sepsis were found between diabetic and non-diabetic patients. Clinically relevant infections with fever > 37 °C were found in 9.1% and 1.5% (p < 0.001) in diabetic and non-diabetic patients, respectively. Trimethoprim-sulphametoxazole and fluoroquinolones were six times more efficient than Cefixime in non-diabetic patients. Fluoroquinolones confirmed the same effect in diabetic patients although the level of resistance in the period of study decreased only from 56 to 46%.

conclusionFluoroquinolones were active in antibiotic prophylaxis of diabetic patients who had undergone to TRUSPB independently from the level of bacterial resistance found in the community. These results conflict with the recent European warning and support the Japanese and American guidelines on the topic.

Indexed as

Bacterial InfectionsDiabetes MellitusAnti-Bacterial AgentsAntibiotic ProphylaxisBiopsyFluoroquinolonesHumansMaleProstateRectumAnti-Bacterial AgentsFluoroquinolonesAntibiotic prophylaxisAntibiotic resistanceFluoroquinolonesInfectionProstate biopsy

Identifiers

PMID35689105
PMCPMC9279202
OpenAlexW4281773823

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.