Trial reportScientific reports2022
Fostering eating after stroke (FEASt) trial for improving post-stroke dysphagia with non-invasive brain stimulation.
Trial report in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Swallowing therapy for dysphagia in acute and subacute stroke.The Cochrane database of systematic reviews · 2026Pooled it
- Dysphagia Rehabilitation in Dysphagic Patients with Acute or Critical Illness: A Systematic Review and Meta-Analysis.Dysphagia · 2024Pooled it
- Dosage consideration for transcranial direct current stimulation in post-stroke dysphagia: A systematic review and network meta-analysis.Frontiers in neurology · 2023Pooled it
- Effect of transcranial direct current stimulation on swallowing improvement and cortical activity in hemispheric stroke patients: a randomized, controlled trial.Scientific reports · 2025Trial
- Efficacy of Transcranial Direct Current Stimulation Combined with Conventional Swallowing Rehabilitation Training on Post-stroke Dysphagia.Dysphagia · 2023Trial
- Effect on Cognitive Behavioral Therapy Combined With Transcranial Direct Current Stimulation on Anxiety and Depression in Stroke Patients With Dysphagia.Actas espanolas de psiquiatria · 2026Article
- Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017-2025: An update) - endorsed by the European Society for Brain Stimulation (ESBS) and by the International Federation for Clinical Neurophysiology (IFCN).Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Diffusion Tensor Tractography Studies for Causes of Dysphagia After Stroke: A Systematic Review.Brain sciences · 2025Review
- Review
- Using status of secondary prevention medications in post-stroke dysphagia patients: time to raise awareness and develop special formulations.Scientific reports · 2024Article
- Evidence and Recommendations for Acute Stroke Rehabilitation from the Japan Stroke Society: Abridged Secondary Publication of the Japanese-language Version.Progress in rehabilitation medicine · 2024Article
- Narrative Review of Noninvasive Brain Stimulation in Stroke Rehabilitation.Medical science monitor : international medical journal of experimental and clinical research · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Dysphagia is a serious stroke complication but lacks effective therapy. We investigated safety and preliminary efficacy of anodal transcranial direct current stimulation (atDCS) paired with swallowing exercises in improving post-stroke dysphagia from an acute unilateral hemispheric infarction (UHI). We conducted a double-blind, early phase-2 randomized controlled trial, in subjects (n = 42) with moderate-severe dysphagia [Penetration and Aspiration Scale (PAS) score ≥ 4], from an acute-subacute UHI. Subjects were randomized to Low-Dose, High-Dose atDCS or Sham stimulation for 5 consecutive days. Primary safety outcomes were incidence of seizures, neurological, motor, or swallowing function deterioration. Primary efficacy outcome was a change in PAS scores at day-5 of intervention. Main secondary outcome was dietary improvement at 1-month, assessed by Functional Oral Intake (FOIS) score. No differences in pre-defined safety outcomes or adjusted mean changes in PAS, FOIS scores, between groups, were observed. Post-hoc analysis demonstrated that 22 /24 subjects in the combined atDCS group had a clinically meaningful dietary improvement (FOIS score ≥ 5) compared to 8 /14 in Sham (p = 0.037, Fisher-exact). atDCS application in the acute-subacute stroke phase is safe but did not decrease risk of aspiration in this early phase trial. The observed dietary improvement is promising and merits further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.