Evidence map›Paper›PMID 35688964›Full record

ReviewWorld journal of microbiology & biotechnology2022

The industrial versatility of Gluconobacter oxydans: current applications and future perspectives.

Gabrielle Alves Ribeiro da Silva, Simone Santos de Sousa Oliveira, Sara Fernandes Lima, Rodrigo Pires do Nascimento, Andrea Regina de Souza Baptista, Sorele Batista Fiaux

Abstract readReview
In one paragraph

Review in World journal of microbiology & biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  11. Patulin Detoxification by Evolutionarily Divergent Reductases ofJournal of agricultural and food chemistry · 2025
    Article
  12. Article
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  18. Draft genome sequences of twoMicrobiology resource announcements · 2024
    Article
  19. CRISPR/Cpf1-FOKI-induced gene editing inSynthetic and systems biotechnology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabrielle Alves Ribeiro da SilvaGraduate Program in Science and Biotechnology, Biology Institute, Fluminense Federal University (UFF), Niterói-RJ, 24020-141, Brazil. gabriellears@id.uff.br.ORCID http://orcid.org/0000-0001-9552-4031
Simone Santos de Sousa OliveiraGraduate Program in Science and Biotechnology, Biology Institute, Fluminense Federal University (UFF), Niterói-RJ, 24020-141, Brazil.
Sara Fernandes LimaMicrobial Technology Laboratory, Pharmaceutical Technology Department, Faculty of Pharmacy, Fluminense Federal University (UFF), Niterói-RJ, 24241-000, Brazil.
Rodrigo Pires do NascimentoEcology of Microbial Process Laboratory, Biochemical Engineering Department, Chemical School, Technology Center, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro-RJ, 21941-909, Brazil.
Andrea Regina de Souza BaptistaCenter for Microorganisms Investigation, Microbiology and Parasitology Department, Biomedical Institute, Fluminense Federal University (UFF), Niterói-RJ, 24020-141, Brazil.
Sorele Batista FiauxMicrobial Technology Laboratory, Pharmaceutical Technology Department, Faculty of Pharmacy, Fluminense Federal University (UFF), Niterói-RJ, 24241-000, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gluconobacter oxydans is a well-known acetic acid bacterium that has long been applied in the biotechnological industry. Its extraordinary capacity to oxidize a variety of sugars, polyols, and alcohols into acids, aldehydes, and ketones is advantageous for the production of valuable compounds. Relevant G. oxydans industrial applications are in the manufacture of L-ascorbic acid (vitamin C), miglitol, gluconic acid and its derivatives, and dihydroxyacetone. Increasing efforts on improving these processes have been made in the last few years, especially by applying metabolic engineering. Thereby, a series of genes have been targeted to construct powerful recombinant strains to be used in optimized fermentation. Furthermore, low-cost feedstocks, mostly agro-industrial wastes or byproducts, have been investigated, to reduce processing costs and improve the sustainability of G. oxydans bioprocess. Nonetheless, further research is required mainly to make these raw materials feasible at the industrial scale. The current shortage of suitable genetic tools for metabolic engineering modifications in G. oxydans is another challenge to be overcome. This paper aims to give an overview of the most relevant industrial G. oxydans processes and the current strategies developed for their improvement.

Indexed as

Gluconobacter oxydansAcetic AcidBiotechnologyFermentationMetabolic EngineeringAcetic AcidBioprocessDihydroxyacetoneGluconatesMetabolic engineeringMiglitolVitamin C

Identifiers

PMID35688964
PMCPMC9187504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.