ArticleCommunications biology2022
The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Thermodynamics of consciousness: Non-equilibrium brain dynamics track conscious states.Cell reports · 2026Article
- Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.Human brain mapping · 2026Article
- A canary in the mind: A single baseline brain scan predicts adolescent depression and anxiety one year later.medRxiv : the preprint server for health sciences · 2026Article
- Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains.Nature human behaviour · 2026Article
- Competitive interactions shape mammalian brain network dynamics and computation.Nature neuroscience · 2026Article
- The turbulent brain: Modeling vortex interactions for understanding human cognition.Network neuroscience (Cambridge, Mass.) · 2026Article
- How the brain predicts timing: distinct network hubs for predicting and evaluating auditory sensory events.Frontiers in neuroscience · 2026Article
- Disrupted Brain Hierarchical Organization in Alzheimer's Disease Progression.medRxiv : the preprint server for health sciences · 2025Article
- Threat-related corticocortical connectivity elicited by rapid auditory looms.Scientific reports · 2025Article
- State-space kinetic Ising model reveals task-dependent entropy flow in sparsely active nonequilibrium neuronal dynamics.Nature communications · 2025Article
- Building blocks of functional connectivity measures for aperiodic electrophysiological brain signals.Neuroimage. Reports · 2025Article
- Reconfiguration of functional brain hierarchy in schizophrenia.Translational psychiatry · 2025Article
- Disrupted hierarchical organization in disorders of consciousness revealed by fluctuation-dissipation deviations.bioRxiv : the preprint server for biology · 2025Article
- Large-scale cortical functional networks are organized in structured cycles.Nature neuroscience · 2025Article
- Perturbing whole-brain models of brain hierarchy: An application for depression following pharmacological treatment.Annals of the New York Academy of Sciences · 2025Article
- Nonequilibrium brain dynamics elicited as the origin of perturbative complexity.PLoS computational biology · 2025Article
- Neural dynamics of semantic control underlying generative storytelling.Communications biology · 2025Article
- Multilevel irreversibility reveals higher-order organization of nonequilibrium interactions in human brain dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Understanding Altered Dynamics in Cocaine Use Disorder Through State Transitions Mediated by Artificial Perturbations.Brain sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Finding precise signatures of different brain states is a central, unsolved question in neuroscience. We reformulated the problem to quantify the 'inside out' balance of intrinsic and extrinsic brain dynamics in brain states. The difference in brain state can be described as differences in the detailed causal interactions found in the underlying intrinsic brain dynamics. We used a thermodynamics framework to quantify the breaking of the detailed balance captured by the level of asymmetry in temporal processing, i.e. the arrow of time. Specifically, the temporal asymmetry was computed by the time-shifted correlation matrices for the forward and reversed time series, reflecting the level of non-reversibility/non-equilibrium. We found precise, distinguishing signatures in terms of the reversibility and hierarchy of large-scale dynamics in three radically different brain states (awake, deep sleep and anaesthesia) in electrocorticography data from non-human primates. Significantly lower levels of reversibility were found in deep sleep and anaesthesia compared to wakefulness. Non-wakeful states also showed a flatter hierarchy, reflecting the diversity of the reversibility across the brain. Overall, this provides signatures of the breaking of detailed balance in different brain states, perhaps reflecting levels of conscious awareness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.