Evidence map›Paper›PMID 35688846›Full record

ArticleScientific reports2022

Intercomparison of radiosensitization induced by gold and iron oxide nanoparticles in human glioblastoma cells irradiated by 6 MV photons.

Danieli B Guerra, Elisa M N Oliveira, Amanda R Sonntag, Patricia Sbaraine, Andre P Fay, Fernanda B Morrone, Ricardo M Papaléo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
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  3. Biogenic ZnO-CuO Nanocomposites Synthesised UsingNanomaterials (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Danieli B GuerraInterdisciplinary Center of Nanoscience and Micro-Nanotechnology, School of Technology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, 90619-900, Brazil. danieli.guerra@acad.pucrs.br.
Elisa M N OliveiraInterdisciplinary Center of Nanoscience and Micro-Nanotechnology, School of Technology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, 90619-900, Brazil.
Amanda R SonntagInterdisciplinary Center of Nanoscience and Micro-Nanotechnology, School of Technology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, 90619-900, Brazil.
Patricia SbaraineDivision of Radiotherapy, São Lucas Hospital of PUCRS, Porto Alegre, 90610-000, Brazil.
Andre P FaySchool of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, 90619-900, Brazil.
Fernanda B MorroneSchool of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, 90619-900, Brazil.
Ricardo M PapaléoInterdisciplinary Center of Nanoscience and Micro-Nanotechnology, School of Technology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, 90619-900, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, an intercomparison of sensitization effects produced by gold (GNP) and dextran-coated iron oxide (SPION-DX) nanoparticles in M059J and U87 human glioblastoma cells was performed using 6 MV-photons. Three variables were mapped: the nanoparticle material, treatment concentration, and cell radiosensitivity. For U87, GNP treatments resulted in high sensitization enhancement ratios (SER[Formula: see text] up to 2.04). More modest effects were induced by SPION-DX, but still significant reductions in survival were achieved (maximum SER[Formula: see text] ). For the radiosensitive M059J, sensitization by both NPs was poor. SER[Formula: see text] increased with the degree of elemental uptake in the cells, but not necessarily with treatment concentration. For GNP, where exposure concentration and elemental uptake were found to be proportional, SER[Formula: see text] increased linearly with concentration in both cell lines. For SPION-DX, saturation of sensitization enhancement and metal uptake occurred at high exposures. Fold change in the [Formula: see text] ratios extracted from survival curves are reduced by the presence of SPION-DX but strongly increased by GNPs , suggesting that sensitization by GNPs occurs mainly via promotion of lethal damage, while for SPION-DX repairable damage dominates. The NPs were more effective in eliminating the radioresistant glioblastoma cells, an interesting finding, as resistant cells are key targets to improve treatment outcome.

Indexed as

GlioblastomaMetal NanoparticlesRadiation-Sensitizing AgentsGoldHumansMagnetic Iron Oxide NanoparticlesPhotonsGoldRadiation-Sensitizing Agents

Identifiers

PMID35688846
PMCPMC9187689

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.