ArticleNature communications2022
Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Ectoderm tensile stress controls mesoderm internalization during embryo gastrulation.Nature communications · 2026Article
- A model for boundary-driven tissue morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Studying gastrulation by invagination: The bending of a cell sheet by mechanical cell properties using 3D deformable cell based simulations.PLoS computational biology · 2025Article
- Localized tension-induced giant folding in unstructured elastic sheets.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Nuclear position controls the activity of cortical actomyosin networks powering simultaneous morphogenetic events.Nature communications · 2025Article
- Article
- Viscous shear is a key force in Drosophila ventral furrow morphogenesis.Development (Cambridge, England) · 2024Article
- A mechanical transition from tension to buckling underlies the jigsaw puzzle shape morphogenesis of histoblasts in the Drosophila epidermis.PLoS biology · 2024Article
- Article
- Mechanical control of neural plate folding by apical domain alteration.Nature communications · 2023Article
- The dynamics and biophysics of shape formation: Common themes in plant and animal morphogenesis.Developmental cell · 2023Review
- Actomyosin pulsing rescues embryonic tissue folding from disruption by myosin fluctuations.Research square · 2023Article
- The mechanics of cephalic furrow formation in the Drosophila embryo.Biophysical journal · 2023Article
- A comprehensive model ofeLife · 2023Article
- From cells to form: A roadmap to study shape emergence in vivo.Biophysical journal · 2023Review
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- Messenger functions of cell death during development and homeostasis.Biochemical Society transactions · 2023Article
- The evolution of gastrulation morphologies.Development (Cambridge, England) · 2023Review
- Homeotic compartment curvature and tension control spatiotemporal folding dynamics.Nature communications · 2023Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 3 countries.
Funding
Abstract
Cell apical constriction driven by actomyosin contraction forces is a conserved mechanism during tissue folding in embryo development. While much is now understood of the molecular mechanism responsible for apical constriction and of the tissue-scale integration of the ensuing in-plane deformations, it is still not clear if apical actomyosin contraction forces are necessary or sufficient per se to drive tissue folding. To tackle this question, we use the Drosophila embryo model system that forms a furrow on the ventral side, initiating mesoderm internalization. Past computational models support the idea that cell apical contraction forces may not be sufficient and that active or passive cell apico-basal forces may be necessary to drive cell wedging leading to tissue furrowing. By using 3D computational modelling and in toto embryo image analysis and manipulation, we now challenge this idea and show that embryo-scale force balance at the tissue surface, rather than cell-autonomous shape changes, is necessary and sufficient to drive a buckling of the epithelial surface forming a furrow which propagates and initiates embryo gastrulation.
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