ArticleExperimental eye research2022
Accommodative movements of the choroid in the optic nerve head region of human eyes, and their relationship to the lens.
Article in Experimental eye research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Annual Solar Cycles: Investigating Seasonal Variations in Southern Norway and Their Potential Role in Human Eye Growth.Investigative ophthalmology & visual science · 2026Article
- A Comparative Clinical Study of 0.50% Versus 0.75% Pilocarpine Eye Drops for Improving Visual Performance in Presbyopia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Interaction Between Near Work and Narrowband Light on Choroidal Thickness.Investigative ophthalmology & visual science · 2026Article
- Presbyopia Progression From the Age of 40 to 79 Years in Glaucoma Patients Treated With Prostaglandin F Receptor Agonists.Translational vision science & technology · 2025Article
- Ciliary muscle traction during accommodation is able to induce optic nerve head deformation.Eye (London, England) · 2025Article
- Choroidal thickness under pilocarpine versus cyclopentolate.Scientific reports · 2025Article
- Comparison of Presbyopia Between Glaucoma Patients Using Prostaglandin F Receptor Agonists and Fixed Combination Therapy.Clinical optometry · 2025Article
- Biomechanical changes occur in myopic choroidal stroma and mirror those in the adjacent sclera.Communications engineering · 2024Article
- The Mirror Theory: Parallels between Open Angle and Angle Closure Glaucoma.Life (Basel, Switzerland) · 2024Review
- Symptomatic Presbyopia may Develop Earlier in Patients With Glaucoma-A Cross-Sectional Retrospective Cohort Study.Translational vision science & technology · 2024Article
- Review
- IMI-The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia.Investigative ophthalmology & visual science · 2023Review
- Intraocular accommodative movements in monkeys; relationship to presbyopia.Experimental eye research · 2022Article
- Age-related posterior ciliary muscle restriction - A link between trabecular meshwork and optic nerve head pathophysiology.Experimental eye research · 2017Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The ciliary muscle (CM) powers the accommodative response, and during accommodation the CM pulls the choroid forward in the region of the ora serrata. Our goal was to elucidate the accommodative movements of the choroid in the optic nerve region in humans and to determine whether these movements are related to changes in the lens dimensions that occur with aging, in the unaccommodated and accommodated state. Both eyes of 12 human subjects (aged 18-51 yrs) were studied. Homatropine (1 drop/5%) was used to relax the ciliary muscle (unaccommodated or "resting" eye) and pilocarpine was used to induce the maximum accommodative response (2 drops/4%) (accommodated eye). Images of the fundus and choroid were collected in the region of the optic nerve (ON) via Spectralis OCT (infrared and EDI mode), and choroidal thickness was determined. Ultrasound biomicroscopy (UBM; 50 MHz, 35 MHz) images were collected in the region of the lens/capsule and ciliary body. OCT and UBM images were collected in the resting and accommodated state. The unaccommodated choroidal thickness declined significantly with age (p = 0.0073, r = 0.73) over the entire age range of the subjects studied (18-51 years old). The choroidal thickness was significantly negatively correlated with lens thickness in the accommodated (p = 0.01) and the unaccommodated states (p = 0.005); the thicker the lens the thinner the choroid. Choroid movements around the optic nerve during accommodation were statistically significant; during accommodation the choroid both thinned and moved centrifugally (outward/away from the optic nerve head). The accommodative choroid movements did not decline significantly with age and were not correlated with accommodative amplitude. Measurement of the choroidal thickness is possible with the Spectralis OCT instrument using EDI mode and can be used to determine the accommodative changes in choroidal thickness. The choroidal thickness decreased with age and during accommodation. It may be that age-related choroidal thinning is due to changes in the geometry of the accommodative apparatus to which it is attached (i.e., ciliary muscle/lens complex) such that when the lens is thicker, the choroid is thinner. Accommodative decrease in choroidal thickness and stretch of the retina/choroid may indicate stress/strain forces in the region of the optic nerve during accommodation and may have implications for glaucoma.
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