Evidence map›Paper›PMID 35687722›Full record

ArticleBiochemistry2022

Metabolic Processing of Selenium-Based Bioisosteres of

Alexis J Apostolos, Karl L Ocius, Thameez M Koyasseril-Yehiya, Carolina Santamaria, José Rogério A Silva, Jerônimo Lameira, Cláudio N Alves, M Sloan Siegrist, Marcos M Pires

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Activity Profiling of Mycobacterial L,D-Transpeptidases.bioRxiv : the preprint server for biology · 2026
    Article
  3. Intravital imaging of translocated bacteria via fluorogenic labeling of gut microbiota in situ.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alexis J ApostolosDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Karl L OciusDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Thameez M Koyasseril-YehiyaDepartment of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003-9298, United States.
Carolina SantamariaMolecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, Massachusetts 01003-9298, United States.
José Rogério A SilvaLaboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, Pará 66075-110, Brazil.ORCID 0000-0003-2310-5107
Jerônimo LameiraLaboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, Pará 66075-110, Brazil.ORCID 0000-0001-7270-1517
Cláudio N AlvesLaboratório de Planejamento e Desenvolvimento de Fármacos, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, Pará 66075-110, Brazil.ORCID 0000-0001-6576-4229
M Sloan SiegristMolecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, Massachusetts 01003-9298, United States.
Marcos M PiresDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.ORCID 0000-0002-5676-0725
Universidade Federal do Pará · BRUniversity of Massachusetts Amherst · USUniversity of Virginia · US

Funding

Unraveling Bacterial Cell Wall Biosynthesis and Sensing via Synthetic AnalogsR35GM124893 · NIGMS · UNIVERSITY OF VIRGINIA · PI Marcos M. Pires · 2017 to 2026
$3.6M
Chemical detection of Mycobacterium tuberculosis growth and antibiotic response during infectionDP2AI138238 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI SIEGRIST, MARY SLOAN · 2017 to 2017
$2.3M
High-speed and high-resolution Zeiss880 multiphoton microscopy systemS10OD025156 · OD · UNIVERSITY OF VIRGINIA · PI PERIASAMY, AMMASI · 2019 to 2019
$600k
NIAID NIH HHS DP2 AI138238NIGMS NIH HHS R35 GM124893NIH HHS S10 OD025156
6 · The paper itself

Abstract

A primary component of all known bacterial cell walls is the peptidoglycan (PG) layer, which is composed of repeating units of sugars connected to short and unusual peptides. The various steps within PG biosynthesis are targets of potent antibiotics as proper assembly of the PG is essential for cellular growth and survival. Synthetic mimics of PG have proven to be indispensable tools to study the bacterial cell structure, growth, and remodeling. Yet, a common component of PG,

Indexed as

MycobacteriumSeleniumCell WallDiaminopimelic AcidPeptidoglycanDiaminopimelic AcidPeptidoglycanSelenium

Identifiers

PMID35687722
PMCPMC9275119
OpenAlexW4281984630

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.