Evidence map›Paper›PMID 35687698›Full record

ArticleScience immunology2022

NuRD complex recruitment to Thpok mediates CD4

Yayi Gao, Monica Zamisch, Melanie Vacchio, Laura Chopp, Thomas Ciucci, Elliott L Paine, Gaelyn C Lyons, Jia Nie, Qi Xiao, Ekaterina Zvezdova and 4 more

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Cytotoxic CD4Signal transduction and targeted therapy · 2026
    Review
  3. Review
  4. Article
  5. T Cell Development: From T-Lineage Specification to Intrathymic Maturation.Advances in experimental medicine and biology · 2025
    Review
  6. Article
  7. Zfp281 and Zfp148 control CD4Science immunology · 2023
    Article
  8. Article
  9. T cells in health and disease.Signal transduction and targeted therapy · 2023
    Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Yayi GaoLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0003-4662-9552
Monica ZamischLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Melanie VacchioLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-5407-6439
Laura ChoppLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-6494-4439
Thomas CiucciLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-5828-0207
Elliott L PaineCollaborative Protein Technology Resource, Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-5575-297X
Gaelyn C LyonsCollaborative Protein Technology Resource, Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-8933-4693
Jia NieLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Qi XiaoLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Ekaterina ZvezdovaSection on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
Paul E LoveSection on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.ORCID 0000-0002-6682-7372
Charles R VinsonLaboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Lisa M JenkinsImmunology Graduate Group, University of Pennsylvania Medical School, Philadelphia, PA, USA.ORCID 0000-0003-1245-1338
Rémy BosselutLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0003-2033-1790
National Cancer Institute · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institutes of Health · USUniversity of Pennsylvania · US

Funding

Genes and signals controlling mammalian hematopoiesis.ZIAHD001803 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LOVE, PAUL E · 2009 to 2025
$36.9M
Genetic Analysis of T-cell DifferentiationZIABC010671 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BOSSELUT, REMY · 2009 to 2025
$34.3M
CPTR - Mass Spectrometry UnitZICBC011430 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JENKINS, LISA · 2012 to 2025
$9.4M
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

Although BTB-zinc finger (BTB-ZF) transcription factors control the differentiation of multiple hematopoietic and immune lineages, how they function is poorly understood. The BTB-ZF factor Thpok controls intrathymic CD4

Indexed as

CD4-Positive T-LymphocytesMi-2 Nucleosome Remodeling and Deacetylase ComplexCell DifferentiationCell LineageTranscription FactorsMi-2 Nucleosome Remodeling and Deacetylase ComplexTranscription Factors

Identifiers

PMID35687698
PMCPMC9484726
OpenAlexW4281932832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.