Evidence map›Paper›PMID 35687692›Full record

ArticleScience advances2022

The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating

Han Yang, Xia Ting, Yue-Hang Geng, Yuntao Xie, Jovia L Nierenberg, Yan-Fei Huo, Yan-Ting Zhou, Yang Huang, Yu-Qing Yu, Xin-Yao Yu and 6 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 3 countries.

Han YangDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.ORCID 0000-0002-9150-8146
Xia TingDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.ORCID 0000-0001-5187-1082
Yue-Hang GengDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.
Yuntao XieBreast Center, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, China.
Jovia L NierenbergDepartment of Epidemiology and Biostatistics, University of California, San Francisco School of Medicine, San Francisco, CA, USA.ORCID 0000-0003-2376-6714
Yan-Fei HuoDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.
Yan-Ting ZhouDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.
Yang HuangDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.
Yu-Qing YuDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.
Xin-Yao YuDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.
Xiao-Fei LiDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.
Elad ZivInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2324-2884
Hongquan ZhangDepartment of Anatomy, Histology and Embryology, Peking University Health Science Center, Beijing 100191, China.
Wei-Gang FangDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.
Yin ShenInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9901-5613
Xin-Xia TianDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China.ORCID 0000-0002-1593-4987
Peking University · CNUniversity of California, San Francisco · US

Funding

Genetics of mammographic density and breast cancer risk in LatinasK24CA169004 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZIV, ELAD · 2012 to 2021
$1.8M
Training in the Molecular & Genetic Epidemiology of CancerT32CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, IONA C, ZIV, ELAD · 2020 to 2024
$1.8M
NCI NIH HHS K24 CA169004NCI NIH HHS T32 CA112355
6 · The paper itself

Abstract

Most genome-wide association study (GWAS)-identified breast cancer-associated causal variants remain uncharacterized. To provide a framework of understanding GWAS-identified variants to function, we performed a comprehensive study of noncoding regulatory variants at the

Indexed as

Genome-Wide Association StudyNeoplasmsAllelesAnimalsGenetic Predisposition to DiseaseMiceNetrinsPolymorphism, Single NucleotideWnt Signaling PathwayNetrinsNtn4 protein, mouse

Identifiers

PMID35687692
PMCPMC9187238
OpenAlexW4281933043

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.