Evidence map›Paper›PMID 35687680›Full record

ArticleScience advances2022

Daily changes in light influence mood via inhibitory networks within the thalamic perihabenular nucleus.

Tenley Weil, K M Daly, Hector Yarur Castillo, Michael B Thomsen, Huikun Wang, Maria E Mercau, Samer Hattar, Hugo Tejeda, Diego C Fernandez

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Prolonged Light Exposure Induces Long-Lasting Retinal Wave Plasticity via Retrograde Melanopsin-Dopamine Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Effects of light on brain-state dynamics and energy landscape.Network neuroscience (Cambridge, Mass.) · 2026
    Article
  6. Article
  7. Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Tenley WeilSection on Light and Circadian Rhythms (SLCR), National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-7253-6638
K M DalySection on Light and Circadian Rhythms (SLCR), National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-7417-6215
Hector Yarur CastilloUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-8549-3315
Michael B ThomsenSection on Light and Circadian Rhythms (SLCR), National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
Huikun WangUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-8556-3504
Maria E MercauDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.ORCID 0000-0001-6971-8676
Samer HattarSection on Light and Circadian Rhythms (SLCR), National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3124-9525
Hugo TejedaUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-2222-6222
Diego C FernandezSection on Light and Circadian Rhythms (SLCR), National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-4363-1318
National Institute of Mental Health · USNational Institutes of Health · USJohns Hopkins University · USYale University · US

Funding

Section on Light and Circadian RhythmsZIAMH002964 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI HATTAR, SAMER · 2017 to 2025
$24.1M
Unit of Neuromodulation and Synaptic IntegrationZIAMH002970 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI TEJEDA, HUGO · 2019 to 2025
$11.1M
Intramural NIH HHS ZIA MH002964
6 · The paper itself

Abstract

Exposure to irregular lighting schedules leads to deficits in affective behaviors. The retino-recipient perihabenular nucleus (PHb) of the dorsal thalamus has been shown to mediate these effects in mice. However, the mechanisms of how light information is processed within the PHb remains unknown. Here, we show that the PHb contains a distinct cluster of GABAergic neurons that receive direct retinal input. These neurons are part of a larger inhibitory network composed of the thalamic reticular nucleus and zona incerta, known to modulate thalamocortical communication. In addition, PHb

Identifiers

PMID35687680
PMCPMC9187232
OpenAlexW4281682505

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.