GuidelinePain medicine (Malden, Mass.)2022
Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 5th Edition.
Guideline in Pain medicine (Malden, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 118 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Spinal Cord Stimulation on Thermal Forward Looking InfraRed (FLIR) Imaging in Complex Regional Pain Syndrome (CRPS)
A Feasibility Study of a Combination of Graded Pain Exposure and Graded Motor Imagery in People With Complex Regional Pain Syndrome Type 1
Identifying Factors Associated With Acute Pain Exacerbation in Children With Complex Regional Pain Syndrome (CRPS): A Novel Research Plan
The Effect of Ultrasound-Guided Stellate Ganglion Block on Pain, Functionality, and Quality of Life in Type 1 Complex Regional Pain Syndrome in Stroke Patients
Who cites it
118 citing papers in PubMed, 6 syntheses or guidelines pooled it, 197 citations in OpenAlex.
- Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach From the Writing Committee of the American Society for Apheresis: The Tenth Special Issue.Journal of clinical apheresis · 2026Guideline
- A Systematic Critical Appraisal of Clinical Practice Guidelines for Non-Pharmacological Conservative Management of Complex Regional Pain Syndrome (CRPS) Using the AGREE-II Instrument.Journal of evaluation in clinical practice · 2026Pooled it
- Touch-based interventions, biofield therapies, and hypnosis for pain management: a scoping review of complementary approaches in physiotherapy.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- Effects of transcutaneous electrical nerve stimulation in complex regional pain syndrome: a systematic review.Pain management · 2025Pooled it
- Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Pooled it
- EMG biofeedback combined with rehabilitation training may be the best physical therapy for improving upper limb motor function and relieving pain in patients with the post-stroke shoulder-hand syndrome: A Bayesian network meta-analysis.Frontiers in neurology · 2022Pooled it
- Mesotherapy With Lidocaine and Ketamine in Complex Regional Pain Syndrome Type 1: A Randomized Double-Blind Trial.Pain practice : the official journal of World Institute of Pain · 2026Trial
- Cognitive Function in Patients With Complex Regional Pain Syndrome (CRPS).European journal of pain (London, England) · 2025Trial
- Sustained symptom reduction in complex regional pain syndrome with a novel home-based virtual reality program: a pilot study.Frontiers in neurology · 2025Trial
- Effects of mirror therapy in post-traumatic complex regional pain syndrome type-1: a randomized controlled study.Journal of rehabilitation medicine · 2024Trial
- Randomized controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in adults with complex regional pain syndrome.Pain medicine (Malden, Mass.) · 2023Trial
- Management of Neuropathic Pain in Complex Regional Pain Syndrome: A Comprehensive Review.Pain practice : the official journal of World Institute of Pain · 2026Review
- Lateral Decubitus Positioning Increases Pleura-Plexus Distance in Ultrasound-Guided Supraclavicular Brachial Plexus Targeting.Pain and therapy · 2026Article
- Sleep Disturbances in Patients with Complex Regional Pain Syndrome: A Pilot Exploratory Study on Pain Characteristics, Functional Impairment, and Psychological Factors.Brain sciences · 2026Article
- Complex regional pain syndrome research trends: A bibliometric analysis of the last 3 decades (1993-2025).Medicine · 2026Article
- Restoring physical function through intensive visual simulation in a ballet dancer with complex regional pain syndrome.Journal of rehabilitation medicine · 2026Article
- Evidence-Based Therapeutic Methods for Reflex Sympathetic Dystrophy: A Systematic Review.Cureus · 2026Review
- Mechanisms Underlying Pain Avoidance in Complex Regional Pain Syndrome.European journal of pain (London, England) · 2026Observational
- Spinal cord stimulation for atypical anterior chest wall complex regional pain syndrome: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Rehabilitation outcomes in patients with complex regional pain syndrome of the ankle-foot complex: a single-center observational study.BMC musculoskeletal disorders · 2026Observational
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been some modest recent advancements in the research of Complex Regional Pain Syndrome, yet the amount and quality of the work in this complicated multifactorial disease remains low (with some notable exceptions; e.g., the recent work on the dorsal root ganglion stimulation). The semi-systematic (though in some cases narrative) approach to review is necessary so that we might treat our patients while waiting for "better research." This semi-systematic review was conducted by experts in the field, (deliberately) some of whom are promising young researchers supplemented by the experience of "elder statesman" researchers, who all mention the system they have used to examine the literature. What we found is generally low- to medium-quality research with small numbers of subjects; however, there are some recent exceptions to this. The primary reason for this paucity of research is the fact that this is a rare disease, and it is very difficult to acquire a sufficient sample size for statistical significance using traditional statistical approaches. Several larger trials have failed, probably due to using the broad general diagnostic criteria (the "Budapest" criteria) in a multifactorial/multi-mechanism disease. Responsive subsets can often be identified in these larger trials, but not sufficient to achieve statistically significant results in the general diagnostic grouping. This being the case the authors have necessarily included data from less compelling protocols, including trials such as case series and even in some instances case reports/empirical information. In the humanitarian spirit of treating our often desperate patients with this rare syndrome, without great evidence, we must take what data we can find (as in this work) and tailor a treatment regime for each patient.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.