Evidence map›Paper›PMID 35687297›Full record

ArticleLetters in applied microbiology2022

Biologically synthesized silver nanoparticles as potent antibacterial effective against multidrug-resistant Pseudomonas aeruginosa.

C Campo-Beleño, R A Villamizar-Gallardo, L E López-Jácome, E E González, S Muñoz-Carranza, B Franco, R Morales-Espinosa, R Coria-Jimenez, R Franco-Cendejas, M Hernández-Durán and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Letters in applied microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  6. Nanomaterials (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Sustainable, scalable nanotechnology approach using filtrate fromFrontiers in cellular and infection microbiology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Green Silver Nanoparticles: An Antibacterial Mechanism.Antibiotics (Basel, Switzerland) · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Biosynthesized silver nanoparticles prevent bacterial infection in chicken egg model and mitigate biofilm formation on medical catheters.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024
    Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

C Campo-BeleñoDepartamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
R A Villamizar-GallardoDepartamento de Medicina, Facultad de Salud, Universidad de Pamplona, Cúcuta, Norte de Santander, Colombia.
L E López-JácomeInfectious Diseases Division, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
E E GonzálezCentro de Ciencia y Tecnología Nanoescalar, "nanCiTec", Bogotá, Colombia.
S Muñoz-CarranzaDivisión de Ciencias Naturales y Exactas, Departamento de Biología, Universidad de Guanajuato, Guanajuato, Mexico.
B FrancoDivisión de Ciencias Naturales y Exactas, Departamento de Biología, Universidad de Guanajuato, Guanajuato, Mexico.
R Morales-EspinosaDepartamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
R Coria-JimenezLaboratorio de Bacteriología Experimental, Instituto Nacional de Pediatría, Mexico City, Mexico.
R Franco-CendejasInfectious Diseases Division, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
M Hernández-DuránInfectious Diseases Division, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
R Lara-MartínezDepartamento de Biología Celular, Facultad de Ciencias, UNAM, Universidad Nacional Autónoma de México, Mexico City, Mexico.ORCID https://orcid.org/0000-0003-2708-573X
L F Jiménez-GarcíaDepartamento de Biología Celular, Facultad de Ciencias, UNAM, Universidad Nacional Autónoma de México, Mexico City, Mexico.
A M Fernández-PresasDepartamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
R García-ContrerasDepartamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.ORCID https://orcid.org/0000-0001-8475-2282
Universidad Nacional Autónoma de México · MXInstituto Nacional de Rehabilitación · MXUniversidad de Guanajuato · MXInstituto Nacional de Pediatria · MXUniversity of Pamplona · CO

Funding

Consejo Nacional de Ciencia y Tecnología A1-S-8530Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México IN20121
6 · The paper itself

Abstract

Pseudomonas aeruginosa is one of the most worrisome infectious bacteria due to its intrinsic and acquired resistance against several antibiotics and the recalcitrance of its infections; hence, the development of novel antimicrobials effective against multidrug-resistant P. aeruginosa is mandatory. In this work, silver nanoparticles obtained by green synthesis using a leaf extract and fungi were tested against a battery of clinical strains from cystic fibrosis, pneumonia and burnt patients, some of them with multidrug resistance. Both nanoparticles showed a potent antibacterial effect, causing severe damage to the cell wall, membrane and DNA, and inducing the production of reactive oxygen species. Moreover, the nanoparticles derived from fungi showed synergistic antibacterial effects with the antibiotics meropenem and levofloxacin for some clinical strains and both kinds of nanoparticles were nontoxic for larvae of the moth Galleria mellonella, encouraging further research for their implementation in the treatment of P. aeruginosa infections.

Indexed as

Metal NanoparticlesPseudomonas InfectionsAnti-Bacterial AgentsDrug Resistance, Multiple, BacterialHumansLevofloxacinMeropenemMicrobial Sensitivity TestsPlant ExtractsPseudomonas aeruginosaReactive Oxygen SpeciesSilverAnti-Bacterial AgentsLevofloxacinMeropenemPlant ExtractsReactive Oxygen SpeciesSilveractivityantimicrobialsmechanisms of actionpseudomonadsresistance

Identifiers

PMID35687297
PMCPMC9543579
OpenAlexW4281639105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.