Evidence map›Paper›PMID 35687295›Full record

SynthesisBiological trace element research2023

Association of Selenium Levels with Preeclampsia: A Systematic Review and Meta-analysis.

Hamdan Z Hamdan, Sumaia Z Hamdan, Ishag Adam

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Biological trace element research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Selenium: 48-year journey of global clinical trials.Molecular and cellular biochemistry · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Hamdan Z HamdanDepartment of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, P.O. BOX. 991, Unaizah, Kingdom of Saudi Arabia. h.abualbasher@qu.edu.sa.ORCID http://orcid.org/0000-0001-9269-8239
Sumaia Z HamdanFaculty of Medicine, Al-Neelain University, Khartoum, Sudan.
Ishag AdamDepartment of Obstetrics and Gynecology, Unaizah College of Medicine, Qassim University, Unaizah, Saudi Arabia.ORCID http://orcid.org/0000-0001-5031-7741
Qassim University · SAAl-Neelain University · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several observational studies have shown inconclusive findings on the association between selenium levels and preeclampsia. This systematic review and meta-analysis was conducted to clarify the association between selenium levels and preeclampsia. The databases PubMed, Google Scholar, ScienceDirect, and the Cochrane Library were searched for studies which investigated selenium levels with preeclampsia and which were published up to April 2022. The overall standardized mean differences (SMD) of selenium levels between cases and controls were measured. Sensitivity analysis, reporting bias, subgroup analysis, and meta-regression were performed for the estimate. The meta-analysis was calculated using the "meta" package in the open-source software R. A total of 26 studies with 1855 preeclampsia cases compared with 3728 healthy pregnant controls were included. The level of selenium was significantly lower in cases of preeclampsia compared with the controls [SMD =  - 0.85; 95% confidence interval (CI): (- 1.46, - 0.25); P =  < 0.01). As there was significant heterogeneity [I

Indexed as

Pre-EclampsiaSeleniumFemaleHumansPregnancySeleniumMeta-analysisNormotensivePreeclampsiaPregnancySeleniumSystematic reviewTrace elements

Identifiers

PMID35687295
OpenAlexW4281853101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.