Evidence map›Paper›PMID 35687119›Full record

ArticleJournal of the American Society for Mass Spectrometry2022

Exploring the Conformational and Binding Dynamics of HMGA2·DNA Complexes Using Trapped Ion Mobility Spectrometry-Mass Spectrometry.

Kevin Jeanne Dit Fouque, Sarah N Sipe, Alyssa Garabedian, German Mejia, Linjia Su, Md Lokman Hossen, Prem P Chapagain, Fenfei Leng, Jennifer S Brodbelt, Francisco Fernandez-Lima

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Enhancing the Depth of Analyses with Next-Generation Ion Mobility Experiments.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kevin Jeanne Dit FouqueDepartment of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.
Sarah N SipeDepartment of Chemistry, University of Texas, Austin, Texas 78712 United States.
Alyssa GarabedianDepartment of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.
German MejiaDepartment of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.
Linjia SuDepartment of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.
Md Lokman HossenDepartment of Physics, Florida International University, Miami, Florida 33199, United States.
Prem P ChapagainDepartment of Physics, Florida International University, Miami, Florida 33199, United States.ORCID 0000-0002-0999-4975
Fenfei LengDepartment of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.ORCID 0000-0002-9024-1216
Jennifer S BrodbeltDepartment of Chemistry, University of Texas, Austin, Texas 78712 United States.ORCID 0000-0003-3207-0217
Francisco Fernandez-LimaDepartment of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.ORCID 0000-0002-1283-4390
Florida International University · USThe University of Texas at Austin · US

Funding

Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological MoleculesR35GM139658 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI BRODBELT, JENNIFER S. · 2021 to 2025
$2.9M
Targeting transcription-coupled DNA supercoiling for discovering antibiotics against bacterial DNA gyraseR21AI125973 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI LENG, FENFEI · 2017 to 2018
$478k
NIAID NIH HHS R21 AI125973NIGMS NIH HHS R35 GM139658
6 · The paper itself

Abstract

The mammalian high mobility group protein AT-hook 2 (HMGA2) is an intrinsically disordered DNA-binding protein expressed during embryogenesis. In the present work, the conformational and binding dynamics of HMGA2 and HMGA2 in complex with a 22-nt (DNA

Indexed as

HMGA2 ProteinIon Mobility SpectrometryAnimalsDNAMammalsTandem Mass SpectrometryDNAHMGA2 Protein

Identifiers

PMID35687119
PMCPMC9280850
OpenAlexW4281767882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.