Evidence map›Paper›PMID 35686687›Full record

SynthesisJournal of psychopharmacology (Oxford, England)2023

Intermittent selective serotonin reuptake inhibitors for premenstrual syndromes: A systematic review and meta-analysis of randomised trials.

Thomas J Reilly, Phoebe Wallman, Ivana Clark, Clare-Louise Knox, Michael C Craig, David Taylor

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychopharmacology (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Thomas J ReillyDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0001-6890-918X
Phoebe WallmanPharmacy Department, Maudsley Hospital, South London and Maudsley NHS Foundation Trust, London, UK.ORCID 0000-0003-4084-6302
Ivana ClarkPharmacy Department, Maudsley Hospital, South London and Maudsley NHS Foundation Trust, London, UK.
Clare-Louise KnoxDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Michael C CraigDepartment of Forensic & Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
David TaylorPharmacy Department, Maudsley Hospital, South London and Maudsley NHS Foundation Trust, London, UK.ORCID 0000-0002-2557-1710
King's College London · GBSouth London and Maudsley NHS Foundation Trust · GBNational Health Service · GB

Funding

Medical Research Council MR/W015943/1Medical Research Council MR/W015943/2
6 · The paper itself

Abstract

backgroundIntermittent (luteal phase) dosing of selective serotonin reuptake inhibitors is one treatment strategy for premenstrual syndromes such as premenstrual dysphoric disorder. This avoids the risk of the antidepressant withdrawal syndrome associated with long-term continuous dosing.

aimsTo compare intermittent dosing to continuous dosing in terms of efficacy and acceptability.

methodsWe searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, PsycINFO, PubMed and CINAHL for randomised trials of intermittent compared with continuous dosing of selective serotonin reuptake inhibitors in premenstrual syndromes. We extracted response rates, dropout rates and changes in symptom scores. We used random effects meta-analyses to pool study-level data and calculated odds ratio for dichotomous data and standardised mean difference for continuous data. Risk of bias was assessed using the Cochrane risk-of-bias tool. The study was registered with PROSPERO (CRD42020224176).

resultsA total of 1841 references were identified, with eight studies being eligible for analysis, consisting of a total of 460 participants. All included studies provided response rates, six provided dropout rates and five provided symptom scores. There was no statistically significant differences between intermittent and continuous dosing in terms of response rate (odds ratio: 1.0, 95% confidence interval (CI): 0.23-4.31,

conclusionSince intermittent dosing avoids the potential for withdrawal symptoms, it should be considered more commonly in this patient population.

Indexed as

Premenstrual Dysphoric DisorderPremenstrual SyndromeAntidepressive AgentsFemaleHumansRandomized Controlled Trials as TopicSelective Serotonin Reuptake InhibitorsAntidepressive AgentsSelective Serotonin Reuptake Inhibitorsmeta-analysisPremenstrual dysphoric disorderpremenstrual syndromerandomised controlled trialserotonin uptake inhibitors

Identifiers

PMID35686687
PMCPMC10074750
OpenAlexW4281900807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.