ArticleBJPsych open2022
Neural correlates of acute post-traumatic dissociation: a functional neuroimaging script-driven imagery study.
Article in BJPsych open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Trauma-related dissociation and the autonomic nervous system: a systematic literature review of psychophysiological correlates of dissociative experiencing in PTSD patients.European journal of psychotraumatology · 2022Pooled it
- Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study.Psychopharmacology · 2024Trial
- Exploring the relationship between dissociative experiences and recovery in psychosis: cross-sectional study.BJPsych bulletin · 2026Article
- The Induction of Dissociative States: A Meta-Analysis.Biological psychiatry global open science · 2025Article
- Biomarkers of dissociation.BJPsych open · 2023Article
- A pharmacological challenge paradigm to assess neural signatures of script-elicited acute dissociation in women with post-traumatic stress disorder.BJPsych open · 2023Article
- Imaging dissociation in post-traumatic stress disorder.BJPsych open · 2023Article
- Association of adverse childhood experiences and cortical neurite density alterations with posttraumatic stress disorder symptoms in autism spectrum disorder.Frontiers in psychiatry · 2023Article
- Human cerebellum and corticocerebellar connections involved in emotional memory enhancement.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Altered brain activity and functional connectivity after MDMA-assisted therapy for post-traumatic stress disorder.Frontiers in psychiatry · 2022Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCurrent neurobiological models of post-traumatic stress disorder (PTSD) assume excessive medial frontal activation and hypoactivation of cortico-limbic regions as neural markers of post-traumatic dissociation. Script-driven imagery is an established experimental paradigm that is used to study acute dissociative reactions during trauma exposure. However, there is a scarcity of experimental research investigating neural markers of dissociation; findings from existing script-driven neuroimaging studies are inconsistent and based on small sample sizes.
aimsThe current aim was to identify the neural correlates of acute post-traumatic dissociation by employing the script-driven imagery paradigm in combination with functional magnetic resonance imaging.
methodFunctional neuroimaging data was acquired in 51 female patients with PTSD with a history of interpersonal childhood trauma. Blood-oxygen-level-dependent response during the traumatic (versus neutral) autobiographical memory recall was analysed, and the derived activation clusters were correlated with dissociation measures.
resultsDuring trauma recall, enhanced activation in the cerebellum, occipital gyri, supramarginal gyrus and amygdala was identified. None of the derived clusters correlated significantly with dissociative symptoms, although patients reported increased levels of acute dissociation following the paradigm.
conclusionsThe present study is one of the largest functional magnetic resonance imaging investigations of dissociative neural biomarkers in patients with PTSD undergoing experimentally induced trauma confrontation to elicit symptom-specific brain reactivity. In light of the current reproducibility crisis prominent in neuroimaging research owing to costly and time-consuming data acquisition, the current (null) findings highlight the difficulty of extracting reliable neurobiological biomarkers for complex subjective experiences such as dissociation.
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