Evidence map›Paper›PMID 35686441›Full record

ArticleIntegrative cancer therapies

Milk and Egg Are Risk Factors for Adverse Effects of Capecitabine-Based Chemotherapy in Chinese Colorectal Cancer Patients.

Jinrong Xu, Zeshuai Lin, Jiani Chen, Jian Zhang, Wanqing Li, Rui Zhang, Jin Xing, Zhihuan Ye, Xiaoping Liu, Qianmin Gao and 5 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03030508 (Discovery and Validate of Multi-genetic Biomarkers for Capecitabine in Chinese Colorectal Patients), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03030508 unknown statusnot on this map

Discovery and Validate of Multi-genetic Biomarkers for Capecitabine in Chinese Colorectal Patients

TypeobservationalSponsorShanghai Changzheng HospitalRan2016 to 2019Enrolled300ConditionsColorectal Cancer, CapecitabineArmsNo intervention
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Food group intake and chemotherapy-induced toxicity: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Jinrong XuTaiyuan Institute of Technology, Taiyuan, Shanxi, China.
Zeshuai LinShanxi Medical University, Taiyuan, Shanxi, China.
Jiani ChenSecond Affiliated Hospital of Naval Medical University, Shanghai, China.
Jian ZhangSecond Affiliated Hospital of Naval Medical University, Shanghai, China.
Wanqing LiChengdu Medical College, Chengdu, China.
Rui ZhangChengdu Medical College, Chengdu, China.
Jin XingShanghai University of Medicine & Health Sciences, Shanghai, China.
Zhihuan YeShanghai University of Medicine & Health Sciences, Shanghai, China.
Xiaoping LiuShanghai University of Medicine & Health Sciences, Shanghai, China.
Qianmin GaoSecond Affiliated Hospital of Naval Medical University, Shanghai, China.
Xintao ChenSecond Affiliated Hospital of Naval Medical University, Shanghai, China.
Jingwen ZhaiSecond Affiliated Hospital of Naval Medical University, Shanghai, China.
Houshan YaoSecond Affiliated Hospital of Naval Medical University, Shanghai, China.
Mingming LiSecond Affiliated Hospital of Naval Medical University, Shanghai, China.
Hua WeiSecond Affiliated Hospital of Naval Medical University, Shanghai, China.ORCID 0000-0002-3852-7276
Shanghai Changzheng Hospital · CNShanghai University of Medicine and Health Sciences · CNChengdu Medical College · CNShanxi Medical University · CNTaiyuan Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChemotherapy-induced adverse effects (CIAEs) remain a challenging problem due to their high incidences and negative impacts on treatment in Chinese colorectal cancer (CRC) patients. We aimed to identify risk factors and predictive markers for CIAEs using food/nutrition data in CRC patients receiving post-operative capecitabine-based chemotherapy.

methodsFood/nutrition data from 130 Chinese CRC patients were analyzed. Univariate and multivariate analyses were used to identify CIAE-related food/nutrition factors. Prediction models were constructed based on the combination of these factors. The area under the receiver operating characteristic curve (AUROC) was used to evaluate the discrimination ability of models.

resultsA total of 20 food/nutrition factors associated with CIAEs were identified in the univariate analysis after adjustments for total energy and potential confounding factors. Based on multivariate analysis, we found that, among these factors, dessert, eggs, poultry, and milk were associated with several CIAEs. Most importantly, poultry was an overall protective factor; milk and egg were risk factors for hand-foot syndrome (HFS) and bone marrow suppression (BMS), respectively. Developed multivariate models in predicting grade 1 to 3 CIAEs and grade 2/3 CIAEs both had good discrimination (AUROC values from 0.671 to 0.778, 0.750 to 0.946 respectively), which had potential clinical application value in the early prediction of CIAEs, especially for more severe CIAEs.

conclusionsOur findings suggest that patients with high milk and egg intakes should be clinically instructed to control their corresponding dietary intake to reduce the likelihood of developing HFS and BMS during capecitabine-based chemotherapy, respectively.

trial registrationClinicalTrials.gov Identifier: NCT03030508.

Indexed as

Antimetabolites, AntineoplasticCapecitabineColorectal NeoplasmsDrug-Related Side Effects and Adverse ReactionsAnimalsChinaEggsFluorouracilHand-Foot SyndromeHumansMilkRisk FactorsAntimetabolites, AntineoplasticCapecitabineFluorouracilanemiabone marrow suppressioncapecitabinechemotherapy-induced adverse effectschemotherapy-induced nausea and vomitingcolorectal cancerfood/nutrition factorhand-foot syndrome

Identifiers

PMID35686441
PMCPMC9189551
OpenAlexW4282941489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.