ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2022
Later sleep timing and social jetlag are related to increased inflammation in a population with a high proportion of OSA: findings from the Cleveland Family Study.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Preconception sleep, pregnancy loss, and adverse pregnancy outcomes among women with a history of pregnancy loss.Human reproduction (Oxford, England) · 2025Trial
- Nonlinear relationship between sleep midpoint and osteoarthritis: a cross-sectional study in US adults.Clinical rheumatology · 2026Article
- Sleep midpoint, social jetlag, and cancer risk in the Cancer Prevention Study-3.Cancer causes & control : CCC · 2026Article
- Influence of circadian alignment and sleep timing variability on sex-specific inflammatory markers in healthy adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- A [Journal of neuroinflammation · 2025Article
- Individual associations of self-reported sleep duration, sleep quality, chronotype and social jet lag with infectious disease risk.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Identification and Mendelian randomization validation of pathogenic gene biomarkers in obstructive sleep apnea.Frontiers in neurology · 2024Article
- Multiplex influences on vigilance and biochemical variables induced by sleep deprivation.Frontiers in sports and active living · 2024Article
- Day-to-day deviations in sleep parameters and biological aging: Findings from the NHANES 2011-2014.Sleep health · 2023Article
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- Irregular sleep and cardiometabolic risk: Clinical evidence and mechanisms.Frontiers in cardiovascular medicine · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesTo examine the association between sleep midpoint and inflammation in a population with a large proportion of individuals diagnosed with obstructive sleep apnea syndrome (OSAS), a group that is already prone to increased inflammation.
methodsSubjects from the Cleveland Family Study underwent overnight polysomnography and completed surveys on sleep habits. Morning and evening blood samples were collected and assayed for proinflammatory biomarkers interleukin (IL)-1, IL-6, and tumor necrosis factor α (TNF-α). Linear regression models were used, adjusting for potential confounders and sleep duration.
resultsThe study population included 587 adults (52.3% with OSAS). Mean ± standard deviation weekday sleep midpoint was 3.52 ± 2.09 (3:31 am) and weekend sleep midpoint was 4.46 ± 1.69 (4:28 am). The Mean difference between weekday and weekend sleep midpoint (social jetlag) was 0.94 ± 2.08 hours. After adjusting for OSA severity, greater social jetlag was associated with higher levels of the inflammatory cytokine IL-1 (beta: 0.435 pg/mL, 95% confidence interval [CI]: 0.091 to 0.779). Additionally, later timing of sleep during both the weekdays and the weekends was associated with increased levels of IL-6 (weekday beta: 0.182 pg/mL; 95% CI: 0.013 to 0.350; and weekend beta: 0.188 pg/mL; 95% CI: 0.004 to 0.373). No trends were observed with TNF-α and any sleep exposure.
conclusionsLater sleep timing was associated with elevated levels of IL-6 while increased social jetlag was associated with elevated levels of IL-1. Our results indicate that later sleep schedules and increased social jetlag may lead to higher inflammation, even after controlling for OSA severity. CITATION: Girtman KL, Baylin A, O'Brien LM, Jansen EC. Later sleep timing and social jetlag are related to increased inflammation in a population with a high proportion of OSA: findings from the Cleveland Family Study.
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