Evidence map›Paper›PMID 35686302›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022

Transcriptional Analysis for Tuberculosis in Pregnant Women From the PRegnancy Associated Changes In Tuberculosis Immunology (PRACHITi) Study.

Jyoti S Mathad, Artur T L Queiroz, Ramesh Bhosale, Mallika Alexander, Shilpa Naik, Vandana Kulkarni, Bruno B Andrade, Amita Gupta

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06253715 (Shortened Regimen for Drug-susceptible TB in Children), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06253715 phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Shortened Regimen for Drug-susceptible TB in Children

TypeinterventionalSponsorJohns Hopkins UniversityRan2025 to 2027Enrolled860ConditionsTuberculosis, Tuberculosis, Pulmonary, Tuberculosis, Lymph Node, Mycobacterium TuberculosisArmsIsoniazid, Rifampin, Pyrazinamide, Ethambutol, Rifapentine
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Jyoti S MathadCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
Artur T L QueirozMultinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, Brazil.
Ramesh BhosaleByramjee Jeejeebhoy Government Medical College-Sassoon Government Hospital, Pune, India.
Mallika AlexanderByramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Trials Unit, Pune, India.
Shilpa NaikByramjee Jeejeebhoy Government Medical College-Sassoon Government Hospital, Pune, India.
Vandana KulkarniByramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Trials Unit, Pune, India.
Bruno B AndradeMultinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, Brazil.
Amita GuptaByramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Trials Unit, Pune, India.ORCID 0000-0001-7036-2718
Johns Hopkins University · USFundação Oswaldo Cruz · BRCornell University · US

Funding

The Johns Hopkins Baltimore-Washington-India Clinical Trials Unit (BWI CTU)UM1AI069465 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Charles W. Flexner, Amita Gupta · 2012 to 2026
$34.1M
Impact of Immune Changes of Pregnancy on TuberculosisR01HD081929 · NICHD · JOHNS HOPKINS UNIVERSITY · PI GUPTA, AMITA · 2014 to 2017
$1.7M
Effect of pregnancy and HIV on the development of tuberculosisK23AI129854 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MATHAD, JYOTI S · 2017 to 2021
$1.0M
NIAID NIH HHS K23 AI129854NIAID NIH HHS UM1 AI069465NICHD NIH HHS R01 HD081929
6 · The paper itself

Abstract

A new tuberculosis (TB) diagnostic cartridge assay, which detects a 3-gene TB signature in whole blood, was not diagnostic in women with maternal TB disease in India (area under the curve [AUC] = 0.72). In a cohort of pregnant women, we identified a novel gene set for TB diagnosis (AUC = 0.97) and one for TB progression (AUC = 0.96).

Indexed as

Mycobacterium tuberculosisPregnancy Complications, ParasiticTuberculosisArea Under CurveFamilyFemaleHumansPregnancyPregnant PeopleimmunologypregnancyRNA signaturetranscriptomicstuberculosis

Identifiers

PMID35686302
PMCPMC9761891
OpenAlexW4281776268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.