Evidence map›Paper›PMID 35686052›Full record

ArticleFrontiers in cell and developmental biology2022

Mesenchymal Stem Cells-Derived Exosomes Ameliorate Ischemia/Reperfusion Induced Acute Kidney Injury in a Porcine Model.

Jianni Huang, Hao Cao, Binbin Cui, Xiaoyan Ma, Ling Gao, Chao Yu, Fengchen Shen, Xinyu Yang, Na Liu, Andong Qiu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jianni HuangDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Hao CaoDepartment of Cardiac Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Binbin CuiDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Xiaoyan MaDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Ling GaoTranslational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Chao YuDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Fengchen ShenDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Xinyu YangDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Na LiuDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Andong QiuSchool of Life Science and Technology, Advanced Institute of Translational Medicine, Tongji University, Shanghai, China.
Guangyan CaiDepartment of Nephrology, Chinese PLA General Hospital, Beijing, China.
Shougang ZhuangDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Shanghai East Hospital · CNChinese PLA General Hospital · CNTongji University · CN

Funding

Role of Histone Methyltransferase EZH2 in Acute and Chronic Renal InjuryR01DK113256 · NIDDK · RHODE ISLAND HOSPITAL · PI ZHUANG, SHOUGANG · 2018 to 2021
$1.5M
NIDDK NIH HHS R01 DK113256
6 · The paper itself

Abstract

Exosomes are membrane-enclosed vesicles secreted by cells, containing a variety of biologically active ingredients including proteins, nucleic acids and lipids. In this study, we investigated the therapeutic effects of the exosomes and underlying mechanisms in a miniature pig model of ischemia/reperfusion-induced acute kidney injury (I/R-AKI). The exosomes were extracted from cultured human umbilical cord derived mesenchymal stem cells (hUC-MSCs) and infused into a miniature pig model of I/R AKI. Our results showed that 120 min of unilateral ischemia followed by reperfusion and contralateral nephrectomy resulted in renal dysfunction, severe kidney damage, apoptosis and necroptosis. Intravenous infusion of one dose of exosomes collected from about 4 × 10

Indexed as

acute kidney injuryapoptosisexosomeshuman umbilical cord derived mesenchymal stem cellsischemia/reperfusionmacrophagesnecroptosistranscriptional factors

Identifiers

PMID35686052
PMCPMC9171021
OpenAlexW4281385972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.