Design of the micropump and mass-transfer compartment of a microfluidic system for regular nonenzymatic glucose measurement.

The aim of this paper is to design and numerically simulate the mass-transfer compartment and piezoelectric micropump of an implantable integrated microfluidic device for regular microdialysis-based nonenzymatic measurement of glucose level in diabetic patients. The device function is based on the process that the piezoelectric micropump pumps the dialysis fluid into the mass-transfer compartment microchannels, where the interstitial fluid (ISF) glucose diffusion into this dialysis fluid gives it a glucose content, then detected and measured in the sensor section. This diffusion takes place through the semipermeable membranes located in the microchannels at the base of the hollow microneedles entering the body skin painlessly. The value of dialysis fluid flow rate (1 μL/min) was chosen so that the best achievable recovery factor can be obtained while the size and time delay of system were being kept at the best minimum possible. In the mass-transfer compartment, the number of microneedles, the dimensions of microchannels and the thickness of membranes were selected so as to achieve the best appropriate recovery factor, minimum possible size as well as considering the fabrication feasibility. Furthermore, in the different parts of micropump, the materials and dimensions were chosen so as to provide the needed flow rate with the best minimum voltage, sufficiently small size and fabrication feasibility.