Evidence map›Paper›PMID 35685478›Full record

ArticleGenes & diseases2022

AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells

Chi Heon Kim, Colleen Oliver, Hamid Dar, Hicham Drissi, Steven M Presciutti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Harnessing CRISPR potential for intervertebral disc regeneration strategies.Frontiers in bioengineering and biotechnology · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chi Heon KimDepartment of Orthopaedics, Emory University School of Medicine, Atlanta, GA 30329, USA.
Colleen OliverDepartment of Orthopaedics, Emory University School of Medicine, Atlanta, GA 30329, USA.
Hamid DarDepartment of Orthopaedics, Emory University School of Medicine, Atlanta, GA 30329, USA.
Hicham DrissiDepartment of Orthopaedics, Emory University School of Medicine, Atlanta, GA 30329, USA.
Steven M PresciuttiDepartment of Orthopaedics, Emory University School of Medicine, Atlanta, GA 30329, USA.

Funding

BLRD VA IK2 BX003845
6 · The paper itself

Abstract

Intervertebral disc degeneration is the main contributor to low back pain, now the leading cause of disability worldwide. Gene transfer, either in a therapeutic attempt or in basic research to understand the mechanisms of disc degeneration, is a fascinating and promising tool to manipulate the complex physiology of the disc. Viral vectors based on the adeno-associated virus (AAV) have emerged as powerful transgene delivery vehicles yet a systematic investigation into their respective tropism, transduction efficiency, and relative toxicity have not yet been performed in the disc

Indexed as

Adeno-associated virusBioluminescence imagingCell permeabilization peptideIntervertebral discLightsheet microscopyNucleus pulposus transductionTissue clearing

Identifiers

PMID35685478
PMCPMC9170577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.