Evidence map›Paper›PMID 35685475›Full record

ReviewGenes & diseases2022

Mutational landscape of gastric adenocarcinoma in Latin America: A genetic approach for precision medicine.

Dennis Cerrato-Izaguirre, Yolanda I Chirino, Claudia M García-Cuellar, Miguel Santibáñez-Andrade, Diddier Prada, Angélica Hernández-Guerrero, Octavio Alonso Larraga, Javier Camacho, Yesennia Sánchez-Pérez

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Somatic Mutational Landscape in Mexican Patients:International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Dennis Cerrato-IzaguirreSubdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), Tlalpan, Ciudad de México, CP 14080, Mexico.
Yolanda I ChirinoUnidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Reyes Iztacala, Tlalnepantla de Baz, Estado de México, CP 54090, Mexico.
Claudia M García-CuellarSubdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), Tlalpan, Ciudad de México, CP 14080, Mexico.
Miguel Santibáñez-AndradeSubdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), Tlalpan, Ciudad de México, CP 14080, Mexico.
Diddier PradaSubdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), Tlalpan, Ciudad de México, CP 14080, Mexico.
Angélica Hernández-GuerreroServicio de Endoscopía, Instituto Nacional de Cancerología (INCan), Tlalpan, Ciudad de México, CP 14080, Mexico.
Octavio Alonso LarragaServicio de Endoscopía, Instituto Nacional de Cancerología (INCan), Tlalpan, Ciudad de México, CP 14080, Mexico.
Javier CamachoDepartamento de Farmacología, Centro de Investigación y de Estudios Avanzados del I.P.N. (CINVESTAV), Ciudad de México, CP 07360, Mexico.
Yesennia Sánchez-PérezSubdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), Tlalpan, Ciudad de México, CP 14080, Mexico.
Instituto Nacional de Cancerología · MXAutonomous University of Tlaxcala · MXCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional · MX

Funding

Early Exposure to Persistent Organic Pollutants, Breast Milk Extracellular Vesicles and Abnormal Cardiometabolic ProgrammingR21ES027087 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BACCARELLI, ANDREA, PRADA, DIDDIER GIOVANNI · 2016 to 2017
$438k
NIEHS NIH HHS R21 ES027087
6 · The paper itself

Abstract

Latin-America (LATAM) is the second region in gastric cancer incidence; gastric adenocarcinoma (GA) represents 95% of all cases. We provide a mutational landscape of GA highlighting a) germline pathogenic variants associated with hereditary GA, b) germline risk variants associated with sporadic GA, and c) somatic variants present in sporadic GA in LATAM, and analyze how this landscape can be applied for precision medicine. We found that Brazil, Chile, Colombia, Mexico, Peru, and Venezuela are the countries with more published studies from LATAM explicitly related to GA. Our analysis displayed that different germline pathogenic variants for the

Indexed as

EthnicitiesGenomeLatin AmericaMutationPrecision medicineStomach neoplasms

Identifiers

PMID35685475
PMCPMC9170608
OpenAlexW3159303353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.