Evidence map›Paper›PMID 35685373›Full record

ArticleComputational and structural biotechnology journal2022

Anion-specific structure and stability of guanidinium-bound DNA origami.

Marcel Hanke, Daniel Dornbusch, Christoph Hadlich, Andre Rossberg, Niklas Hansen, Guido Grundmeier, Satoru Tsushima, Adrian Keller, Karim Fahmy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marcel HankePaderborn University, Technical and Macromolecular Chemistry, Warburger Str. 100, Paderborn 33098, Germany.
Daniel DornbuschHelmholtz-Zentrum Dresden-Rossendorf, Institute of Resource Ecology, Bautzner Landstrasse 400, Dresden 01328, Germany.
Christoph HadlichHelmholtz-Zentrum Dresden-Rossendorf, Institute of Resource Ecology, Bautzner Landstrasse 400, Dresden 01328, Germany.
Andre RossbergHelmholtz-Zentrum Dresden-Rossendorf, Institute of Resource Ecology, Bautzner Landstrasse 400, Dresden 01328, Germany.
Niklas HansenPaderborn University, Technical and Macromolecular Chemistry, Warburger Str. 100, Paderborn 33098, Germany.
Guido GrundmeierPaderborn University, Technical and Macromolecular Chemistry, Warburger Str. 100, Paderborn 33098, Germany.
Satoru TsushimaHelmholtz-Zentrum Dresden-Rossendorf, Institute of Resource Ecology, Bautzner Landstrasse 400, Dresden 01328, Germany.
Adrian KellerPaderborn University, Technical and Macromolecular Chemistry, Warburger Str. 100, Paderborn 33098, Germany.
Karim FahmyHelmholtz-Zentrum Dresden-Rossendorf, Institute of Resource Ecology, Bautzner Landstrasse 400, Dresden 01328, Germany.
Helmholtz-Zentrum Dresden-Rossendorf · DEPaderborn University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the folding of DNA into rationally designed DNA origami nanostructures has been studied extensively with the aim of increasing structural diversity and introducing functionality, the fundamental physical and chemical properties of these nanostructures remain largely elusive. Here, we investigate the correlation between atomistic, molecular, nanoscopic, and thermodynamic properties of DNA origami triangles. Using guanidinium (Gdm) as a DNA-stabilizing but potentially also denaturing cation, we explore the dependence of DNA origami stability on the identity of the accompanying anions. The statistical analyses of atomic force microscopy (AFM) images and circular dichroism (CD) spectra reveals that sulfate and chloride exert stabilizing and destabilizing effects, respectively, already below the global melting temperature of the DNA origami triangles. We identify structural transitions during thermal denaturation and show that heat capacity changes Δ

Indexed as

Atomic force microscopyCircular dichroismCounteranionsDenaturationDNA origamiGuanidinium

Identifiers

PMID35685373
PMCPMC9163702
OpenAlexW4281390584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.