ArticleFrontiers in endocrinology2022
Global, Regional, and National Burden of Low Bone Mineral Density From 1990 to 2019: Results From the Global Burden of Disease Study 2019.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Performance of clinical prediction models for identifying postmenopausal osteoporosis: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2026Pooled it
- The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Risk of low bone mineral density in patients with haemophilia: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- Mediterranean Diet, Physical Activity, and Bone Health in Older Adults: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2025Trial
- Burden and temporal trends attributable to low bone mineral density in Mexico, 1990-2023: a global burden of disease analysis.Archives of osteoporosis · 2026Article
- An Anatomically Guided and Optimization-Refined Radiomics Framework for Opportunistic Osteoporosis Assessment from Lumbar Spine MRI.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Global burden of fall-related injuries attributable to low bone mineral density in women aged 50-69 years: inequalities, projections to 2050, and Mendelian randomisation.Journal of global health · 2026Article
- Changes in Oxidative Stress, Inflammatory and Bone Metabolism Biomarkers Following Sulfurous Water Inhalation in Osteopenic Women.International journal of molecular sciences · 2026Article
- [Trends in burden of osteoporosis in China from 1990 to 2023 and analysis of epidemiological factors].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Association between osteoporosis and cardiovascular disease in women and the mediating role of inflammatory biomarkers: based on the NHANES database : Mediating role of inflammatory biomarkers between OP and CVD in women.Immunologic research · 2026Article
- The relationship between the polymorphisms and mutations of OPG gene and bone metabolism in postmenopausal women in northwest China.Journal of orthopaedic surgery and research · 2026Article
- Global Disease Burden of Traumatic Joint Dislocation from 1990 to 2021 and its prediction to 2045.Communications medicine · 2026Article
- Cost-effectiveness analysis of low bone mass prevention in Chinese older men with excessive alcohol consumption: a modelling study.BMJ open · 2026Article
- Physical activity patterns and all-cause mortality in U.S. adults with osteopenia or osteoporosis: A prospective cohort study.Medicine · 2026Article
- The role of gut microbiota in osteoporosis: underlying mechanisms, clinical associations, and emerging biomaterials.Frontiers in immunology · 2026Review
- The recent progression of extracellular vesicles application in osteoporosis.Frontiers in pharmacology · 2026Review
- Pla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis.Nature communications · 2025Article
- Burden of disease and trend of osteoporotic fall-related hip fractures in Ecuador: findings from the global burden disease 2021.Archives of osteoporosis · 2025Article
- Exposure to high altitude is associated with an elevated risk of hip fracture: a retrospective cohort study using data from the CHARLS.BMC geriatrics · 2025Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: We aim to explore the global spatial prevalence and temporal trends of the burden of low bone mineral density (LBMD) worldwide, due to a lack of related studies. Design: Cross-sectional study. Methods: We used data from the Global Burden of Disease Study 2019 to conduct this study. LBMD in the GBD study includes both osteopenia and osteoporosis. The estimation for the prevalence, measured by the summary exposure value (SEV), and burden of LBMD was made in DisMod-MR 2.1, a Bayesian meta-regression tool. Correlation analysis was performed using the Spearman rank order correlation methods. The temporal trends were represented by the estimated annual percentage change (EAPC). Results: In 2019, there were 438 thousand deaths and 16.6 million DALYs attributable to LBMD, increasing by 111.1% and 93.8% respectively, compared to that in 1990. From 1990 to 2019, the prevalence of LBMD has decreased worldwide, but has increased in high-income North America. Some countries, such as the United States, Australia, Canada, and China had increased disability and mortality rates of LBMD with time. Countries with low socio-demographic index (SDI) had higher incidence and mortality rate than those with high SDI. The prevalence of LBMD was lower in males, but the attributable disability and mortality were higher in males in all years from 1990 to 2019. Conclusion: With population aging, countries worldwide, especially those with low-SDI, will face increasing challenges in reducing the burden attributable to LBMD and osteoporosis. The treatment of osteoporosis has been overlooked in men for a long time. Effective measures are warranted to control the prevalence and burden of LBMD.
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