Evidence map›Paper›PMID 35684552›Full record

ArticleMolecules (Basel, Switzerland)2022

Anti-Proliferative and Cytoprotective Activity of Aryl Carbamate and Aryl Urea Derivatives with Alkyl Groups and Chlorine as Substituents.

Maxim Oshchepkov, Leonid Kovalenko, Antonida Kalistratova, Maria Ivanova, Galina Sherstyanykh, Polina Dudina, Alexey Antonov, Anastasia Cherkasova, Mikhail Akimov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. New Hybrid Ethylenediurea (EDU) Derivatives and Their Phytoactivity.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Maxim OshchepkovDepartment of Chemistry and Technology of Biomedical Drugs, Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, 125047 Moscow, Russia.
Leonid KovalenkoDepartment of Chemistry and Technology of Biomedical Drugs, Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, 125047 Moscow, Russia.
Antonida KalistratovaDepartment of Chemistry and Technology of Biomedical Drugs, Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, 125047 Moscow, Russia.ORCID 0000-0001-6023-7526
Maria IvanovaDepartment of Chemistry and Technology of Biomedical Drugs, Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, 125047 Moscow, Russia.
Galina SherstyanykhShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.
Polina DudinaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.
Alexey AntonovFaculty of Mechanics and Mathematics, Lomonosov Moscow State University, GSP-1, Leninskie Gory, 119991 Moscow, Russia.
Anastasia CherkasovaFaculty of Biotechnology, Lomonosov Moscow State University, GSP-1, Leninskie Gory, 119991 Moscow, Russia.
Mikhail AkimovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.ORCID 0000-0002-7467-4409
D. Mendeleyev University of Chemical Technology of Russia · RUInstitute of Bioorganic Chemistry · RULomonosov Moscow State University · RU

Funding

Ministry of Science and Higher Education of Russian Federation № 075-15-2020-792 (Unique identifier RF 190220X0031)
6 · The paper itself

Abstract

Natural cytokinines are a promising group of cytoprotective and anti-tumor agents. In this research, we synthesized a set of aryl carbamate, pyridyl urea, and aryl urea cytokinine analogs with alkyl and chlorine substitutions and tested their antiproliferative activity in MDA-MB-231, A-375, and U-87 MG cell lines, and cytoprotective properties in H

Indexed as

CarbamatesUreaCell LineChlorineHalogensHydrogen PeroxideStructure-Activity RelationshipCarbamatesChlorineHalogensHydrogen PeroxideUreaanti-stress effectcarbamatescytotoxicityoxamatesoxidative stresssubstituted ureassynthetic cytokinins

Identifiers

PMID35684552
PMCPMC9182529
OpenAlexW4281900802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.