ReviewMolecules (Basel, Switzerland)2022
Leptin in Human Milk-One of the Key Regulators of Nutritional Programming.
Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The association between maternal factors and milk hormone concentrations: a systematic review.Frontiers in nutrition · 2024Pooled it
- Cumulative Household Food Insecurity Is Associated with Adverse Eating Behaviors Among Youth Exposed to Gestational Diabetes in Utero.Nutrients · 2026Article
- Leptin-cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming.Experimental physiology · 2026Review
- Bioactive-Supplemented Infant Formulas and Early Gut-Immune-Endocrine Development: A Narrative Review.International journal of molecular sciences · 2026Review
- Breastfeeding in Infancy and Adult Health: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Reexamining Fat: Exploring Diversity, Plasticity, Development, Functional Implication, and Therapeutic Options.International journal of molecular sciences · 2026Review
- Maternal Determinants of Human Milk Leptin and Their Associations with Neonatal Growth Parameters.Nutrients · 2026Article
- Adipocytokine profiles in maternal obesity: The impact of lipoinflammation on serum, breastmilk, and infant metabolic development.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2025Review
- Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies.International journal of molecular sciences · 2025Review
- Article
- Relevance of Milk Composition to Human Longitudinal Growth from Infancy Through Puberty: Facts and Controversies.Nutrients · 2025Review
- Climate change, evolution, and reproductive health: The impact of water insecurity and heat stress on pregnancy and lactation.Evolution, medicine, and public health · 2025Review
- Influence of Lactation Stage on Content of Neurotrophic Factors, Leptin, and Insulin in Human Milk.Molecules (Basel, Switzerland) · 2024Article
- The interaction of breastfeeding and genetic factors on childhood obesity.European journal of obstetrics & gynecology and reproductive biology: X · 2024Review
- Article
- Gestational Diabetes Mellitus and Colostral Appetite-Regulating Adipokines.International journal of molecular sciences · 2024Article
- Breastfeeding: science and knowledge in pediatric obesity prevention.Frontiers in medicine · 2024Article
- Infant feeding-a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2024Article
- Programming of metabolism by adipokines during development.Nature reviews. Endocrinology · 2023Review
- Maternal high-fat diet decreases milk endocannabinoids with sex-specific changes in the cannabinoid and dopamine signaling and food preference in rat offspring.Frontiers in endocrinology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Breast milk is the optimal food for infants and toddlers, providing basic nutrients. It is also a source of many biologically active substances. Among them are hormones responsible for metabolic balance. One of the hormones taken in with breast milk by a breastfed baby is leptin. This hormone is involved in the regulation of appetite, informing the brain about the body's energy resources. Having the correct mechanisms related to the action of leptin is a factor reducing the risk of obesity. The natural presence of leptin in the composition of breast milk suggests that it has a specific role in shaping the health of a breastfed child. Obesity as a disease of civilization affects more and more people, including children. The development of this disease is multifaceted and determined by many factors, including genetic and environmental factors such as eating habits and low physical activity. Behind obesity, there are complex mechanisms in which many elements of the human body are involved. Understanding the effects of breastfeeding as a natural source of leptin can help prevent childhood obesity and development of this disease in future life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.