Evidence map›Paper›PMID 35684500›Full record

ReviewMolecules (Basel, Switzerland)2022

Natural Antioxidant Evaluation: A Review of Detection Methods.

Jenifer da Silva Mendonça, Rita de Cássia Avellaneda Guimarães, Verônica Assalin Zorgetto-Pinheiro, Carolina Di Pietro Fernandes, Gabriela Marcelino, Danielle Bogo, Karine de Cássia Freitas, Priscila Aiko Hiane, Elaine Silva de Pádua Melo, Marcelo Luiz Brandão Vilela and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 130 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Quality Evaluation and Antioxidant Activity of CultivatedMolecules (Basel, Switzerland) · 2026
    Article
  11. Review
  12. Article
  13. ACS omega · 2025
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jenifer da Silva MendonçaGraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Rita de Cássia Avellaneda GuimarãesGraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Verônica Assalin Zorgetto-PinheiroGraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Carolina Di Pietro FernandesGroup of Spectroscopy and Bioinformatics Applied Biodiversity and Health (GEBABS), Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Gabriela MarcelinoGraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.ORCID 0000-0003-0015-6083
Danielle BogoGraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Karine de Cássia FreitasGraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.ORCID 0000-0002-5813-6088
Priscila Aiko HianeGraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.ORCID 0000-0003-1115-4083
Elaine Silva de Pádua MeloGraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Marcelo Luiz Brandão VilelaSchool of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Valter Aragão do NascimentoGraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.ORCID 0000-0002-9020-8002
Universidade Federal de Mato Grosso do Sul · BR

Funding

National Council for Scientific and Technological Development, Brazil, for the financial support (CNPq: Process No 310621/ 2020-8) 310621/ 2020-8
6 · The paper itself

Abstract

Antioxidants have drawn the attention of the scientific community due to being related to the prevention of various degenerative diseases. The antioxidant capacity has been extensively studied in vitro, and different methods have been used to assess its activity. However, the main issues related to studying natural antioxidants are evaluating whether these antioxidants demonstrate a key role in the biological system and assessing their bioavailability in the organism. The majority of outcomes in the literature are controversial due to a lack of method standardization and their proper application. Therefore, this study aims to compile the main issues concerning the natural antioxidant field of study, comparing the most common in vitro methods to evaluate the antioxidant activity of natural compounds, demonstrating the antioxidant activity in biological systems and the role of the main antioxidant enzymes of redox cellular signaling and explaining how the bioavailability of bioactive compounds is evaluated in animal models and human clinical trials.

Indexed as

AntioxidantsAnimalsBiological AvailabilityOxidation-ReductionAntioxidantsantioxidantantioxidant assaybioactive compoundsin vitro modelsin vivo modelssecondary metabolites

Identifiers

PMID35684500
PMCPMC9182375
OpenAlexW4281957506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.