Evidence map›Paper›PMID 35684455›Full record

ReviewMolecules (Basel, Switzerland)2022

A Prospective Viewpoint on Neurological Diseases and Their Biomarkers.

Mehrukh Zehravi, Janisa Kabir, Rokeya Akter, Sumira Malik, Ghulam Md Ashraf, Priti Tagde, Sarker Ramproshad, Banani Mondal, Md Habibur Rahman, Aurel George Mohan and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 5 countries.

Mehrukh ZehraviDepartment of Clinical Pharmacy Girls Section, Prince Sattam Bin Abdul Aziz University, Alkharj 11942, Saudi Arabia.
Janisa KabirKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.
Rokeya AkterDepartment of Global Medical Science, Wonju College of Medicine, Yonsei University, Gangwon-do, Wonju 26426, Korea.
Sumira MalikAmity Institute of Biotechnology, Amity University Jharkhand, Ranchi, Jharkhand 834001, India.
Ghulam Md AshrafPre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-9820-2078
Priti TagdeAmity Institute of Pharmacy, Amity University, Noida 201301, India.ORCID 0000-0002-0375-9165
Sarker RamproshadDepartment of Pharmacy, Ranada Prasad Shaha University, Narayanganj 1400, Bangladesh.ORCID 0000-0001-9277-2451
Banani MondalDepartment of Pharmacy, Ranada Prasad Shaha University, Narayanganj 1400, Bangladesh.
Md Habibur RahmanDepartment of Global Medical Science, Wonju College of Medicine, Yonsei University, Gangwon-do, Wonju 26426, Korea.ORCID 0000-0001-6099-5693
Aurel George MohanFaculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, Romania.
Simona CavaluFaculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, Romania.ORCID 0000-0001-7810-8925
University of Oradea · ROYonsei University · KRAmity University · INChina Pharmaceutical University · CNKing Abdulaziz University · SAPrince Sattam Bin Abdulaziz University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases (NDDs) are disorders that affect both the central and peripheral nervous systems. To name a few causes, NDDs can be caused by ischemia, oxidative and endoplasmic reticulum (ER) cell stress, inflammation, abnormal protein deposition in neural tissue, autoimmune-mediated neuron loss, and viral or prion infections. These conditions include Alzheimer's disease (AD), Lewy body dementia (LBD), and Parkinson's disease (PD). The formation of β-sheet-rich aggregates of intra- or extracellular proteins in the CNS hallmarks all neurodegenerative proteinopathies. In systemic lupus erythematosus (SLE), numerous organs, including the central nervous system (CNS), are affected. However, the inflammatory process is linked to several neurodegenerative pathways that are linked to depression because of NDDs. Pro-inflammatory signals activated by aging may increase vulnerability to neuropsychiatric disorders. Viruses may increase macrophages and CCR5+ T cells within the CNS during dementia formation and progression. Unlike medical symptoms, which are just signs of a patient's health as expressed and perceived, biomarkers are reproducible and quantitative. Therefore, this current review will highlight and summarize the neurological disorders and their biomarkers.

Indexed as

Alzheimer DiseaseLewy Body DiseaseNeurodegenerative DiseasesBiomarkersHumansProspective StudiesBiomarkersbiomarkersneuroinflammationneurological disorderproteinopathies

Identifiers

PMID35684455
PMCPMC9182418
OpenAlexW4281789640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.