ArticleMolecules (Basel, Switzerland)2022
Effective Components and Molecular Mechanism of Agarwood Essential Oil Inhalation and the Sedative and Hypnotic Effects Based on GC-MS-Qtof and Molecular Docking.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Intranasal essential oils in therapy: advances in clinical applications and delivery mechanisms.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Review
- Mechanisms of Senegenin in Regulating Oxidative Stress and Mitochondria Damage for Neuroprotection in Insomnia: Evidence from In Vivo and In Vitro Models.Molecular neurobiology · 2025Article
- Agarwood Chromone Alleviates Gastric Ulcers by Inhibiting the NF-κB and Caspase Pathways Based on Network Pharmacology and Molecular Docking.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Antidepressant Activity of Agarwood Essential Oil: A Mechanistic Study on Inflammatory and Neuroprotective Signaling Pathways.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Deciphering the roles of bacterial and fungal communities in the formation and quality of agarwood.Stress biology · 2024Article
- Sedative-Hypnotic Effect and Mechanism of Carbon Nanofiber Loaded with Essential Oils ofBiomolecules · 2024Article
- Pharmacology and therapeutic potential of agarwood and agarwood tree leaves in periodontitis.Frontiers in pharmacology · 2024Review
- Exploring the mechanism of agarwood moxa smoke in treating sleep disorders based on GC-MS and network pharmacology.Frontiers in medicine · 2024Article
- Utilizing metabolomics and network analysis to explore the effects of artificial production methods on the chemical composition and activity of agarwood.Frontiers in pharmacology · 2024Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
Agarwood has been used for the administration of hypnotic therapy. Its aromatic scent induces a relaxed state. However, its aromatic constituents and the underlying molecular effect are still unclear. This study aims to determine the active substance and molecular mechanism of the hypnotic effect of agarwood essential oil (AEO) incense inhalation in insomniac mice. Insomnia models were induced by para-chlorophenylalanine (PCPA, 300 mg/kg) in mice. The sleep-promoting effect was evaluated. Neurotransmitter levels and its receptor were detected to explore the molecular mechanism. The effective components were analyzed by GC-Q/TOF-MS of AEO. The binding mechanisms of the core compounds and core targets were verified by molecular docking. These results showed that AEO inhalation could significantly shorten sleep latency and prolong sleep time, inhibit autonomous activity and exert good sedative and sleep-promoting effects. A mechanistic study showed that AEO inhalation increased the levels of γ-aminobutyric acid (GABA
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