Evidence map›Paper›PMID 35684390›Full record

ArticleMolecules (Basel, Switzerland)2022

Discovery of Dipyridamole Analogues with Enhanced Metabolic Stability for the Treatment of Idiopathic Pulmonary Fibrosis.

Meng-Xing Huang, Yan-Quan Chen, Run-Duo Liu, Yue Huang, Chen Zhang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Meng-Xing HuangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Yan-Quan ChenSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Run-Duo LiuSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Yue HuangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Chen ZhangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.ORCID 0000-0002-0447-0961
Sun Yat-sen University · CN

Funding

China Postdoctoral Science Foundation 2020T130152ZXNational Natural Science Foundation of China 82003652
6 · The paper itself

Abstract

Dipyridamole, apart from its well-known antiplatelet and phosphodiesterase inhibitory activities, is a promising old drug for the treatment of pulmonary fibrosis. However, dipyridamole shows poor pharmacokinetic properties with a half-life (T

Indexed as

DipyridamoleIdiopathic Pulmonary FibrosisAnimalsMicrosomes, LiverMolecular Docking SimulationMolecular StructureRatsStructure-Activity RelationshipDipyridamoledipyridamolemetabolic stabilitymolecular dockingphosphodiesterasepulmonary fibrosis

Identifiers

PMID35684390
PMCPMC9182104
OpenAlexW4281982808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.