ArticleMolecules (Basel, Switzerland)2022
Statistical Methods in the Study of Protein Binding and Its Relationship to Drug Bioavailability in Breast Milk.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Rules of Thumb for Estimating Drug Levels in Breast Milk: How Well Do They Work?Clinical pharmacology and therapeutics · 2026Article
- From a Molecule to a Drug: Chemical Features Enhancing Pharmacological Potential.Molecules (Basel, Switzerland) · 2022Article
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Authors and funding
2 authors.
Funding
Abstract
Protein binding (PB) is indicated as the factor most severely limiting distribution in the organism, reducing the bioavailability of the drug, but also minimizing the penetration of xenobiotics into the fetus or the body of a breastfed child. Therefore, PB is an important aspect to be analyzed and monitored in the design of new drug substances. In this paper, several statistical analyses have been introduced to find the relationship between protein binding and the amount of drug in breast milk and to select molecular descriptors responsible for both pharmacokinetic phenomena. Along with descriptors related to the physicochemical properties of drugs, chromatographic descriptors from TLC and HPLC experiments were also used. Both methods used modification of the stationary phase, using bovine serum albumin (BSA) in TLC and human serum albumin (HSA) in HPLC. The use of the chromatographic data in the protein binding study was found to be positive -the most effective application of normal-phase TLC and HPLC
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