Evidence map›Paper›PMID 35684377›Full record

ArticleMolecules (Basel, Switzerland)2022

Efficient Synthesis of 2-Aminopyridine Derivatives: Antibacterial Activity Assessment and Molecular Docking Studies.

Zahira Kibou, Nadia Aissaoui, Ismail Daoud, Julio A Seijas, María Pilar Vázquez-Tato, Nihel Klouche Khelil, Noureddine Choukchou-Braham

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zahira KibouLaboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, BP 119, Tlemcen 13000, Algeria.
Nadia AissaouiLaboratory of the Sustainable Management of Natural Resources in Arid and Semi Aridareas, University Center Salhi Ahmed Naama, BP 66, Naama 45000, Algeria.
Ismail DaoudDépartement des Sciences de la Matière, Université de Mohamed Khider, BP 145 RP, Biskra 07000, Algerie.
Julio A SeijasDepartamento de Química Orgánica, Facultad de Ciencias, Universidad de Santiago de Compostela, A da, Alfonso X El Sabio s/n, 27002 Lugo, Spain.ORCID 0000-0002-5201-8873
María Pilar Vázquez-TatoDepartamento de Química Orgánica, Facultad de Ciencias, Universidad de Santiago de Compostela, A da, Alfonso X El Sabio s/n, 27002 Lugo, Spain.ORCID 0000-0003-3254-710X
Nihel Klouche KhelilLaboratory of Applied Microbiology in Food, Biomedical and Environment (LAMAABE), Department of Biology, Faculty of Nature and Life, Earth and Universe Sciences, University of Tlemcen, Tlemcen 13000, Algeria.
Noureddine Choukchou-BrahamLaboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, BP 119, Tlemcen 13000, Algeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new and suitable multicomponent one-pot reaction was developed for the synthesis of 2-amino-3-cyanopyridine derivatives.

backgroundThis synthesis was demonstrated by the efficient and easy access to a variety of substituted 2-aminopyridines using enaminones as key precursors under solvent-free conditions.

methodsA range of spectroscopic techniques was used to determine and confirm the chemical structures (FTIR,

resultsThe results of the antimicrobial activity indicated that compound

conclusionsOn the basis of the obtained results, compound

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsAminopyridinesGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureStaphylococcus aureusStructure-Activity Relationshipalpha-aminopyridineAminopyridinesAnti-Bacterial AgentsAnti-Infective Agents2-aminopyridine derivativesADME-T predictionantimicrobial studyenaminonesmolecular dockingmulticomponent reactions

Identifiers

PMID35684377
PMCPMC9182143

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.