ArticleMolecules (Basel, Switzerland)2022
A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 5 citations in OpenAlex.
- Expanding Complex Morpholines Using Systematic Chemical Diversity.Organic letters · 2024Article
- Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Iridium-Catalyzed Regio- and Diastereoselective Synthesis of C-Substituted Piperazines.ACS catalysis · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five steps with a high enantiomeric purity. The novel route facilitated, for the first time, the synthesis of 3-phenyl substituted-2-piperazine acetic acid esters that were difficult to achieve using other methods; however, in this case, the products underwent racemization.
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