ArticlePlants (Basel, Switzerland)2022
Wound Healing and Antioxidant Capabilities of
Article in Plants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Total Phenolic, Flavonoid Content, and Antioxidant Activity of Selected Wild Edible Plants from Yemen.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Review
- Bioactive Cyclopeptide Alkaloids and Ceanothane Triterpenoids fromMolecules (Basel, Switzerland) · 2025Article
- Therapeutic efficacy ofFrontiers in nutrition · 2025Review
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- In Vitro and Randomized Controlled Clinical Study of Natural Constituents' Anti-HPV Potential for Treatment of Plantar Warts Supported with In Silico Studies and Network Analysis.Pharmaceuticals (Basel, Switzerland) · 2024Article
- New cytotoxic dammarane type saponins from Ziziphus spina-christi.Scientific reports · 2023Article
- Indian jujube a potential fruit tree to improve the livelihood.Saudi journal of biological sciences · 2023Review
- The wound healing effect of botanicals and pure natural substances used in in vivo models.Inflammopharmacology · 2023Review
- Assessment of the Antioxidant and Antimicrobial Potential ofAntibiotics (Basel, Switzerland) · 2023Article
- Synergistic Effect ofMolecules (Basel, Switzerland) · 2023Article
- Wound Healing Properties of Natural Products: Mechanisms of Action.Molecules (Basel, Switzerland) · 2023Review
- The Potential ofMolecules (Basel, Switzerland) · 2022Article
- Antiulcer Potential ofAntioxidants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LC-HRMS-assisted chemical profiling of Zizyphus mauritiana fruit extract (ZFE) led to the dereplication of 28 metabolites. Furthermore, wound healing activity of ZFE in 24 adult male New Zealand Dutch strain albino rabbits was investigated in-vivo supported by histopathological investigation. Additionally, the molecular mechanism was studied through different in-vitro investigations as well as, studying both relative gene expression and relative protein expression patterns. Moreover, the antioxidant activity of ZFE extract was examined using two in-vitro assays including hydrogen peroxide and superoxide radical scavenging activities that showed promising antioxidant potential. Topical application of the extract on excision wounds showed a significant increase in the wound healing rate (p < 0.001) in comparison to the untreated and MEBO®-treated groups, enhancing TGF-β1, VEGF, Type I collagen expression, and suppressing inflammatory markers (TNF-α and IL-1β). Moreover, an in silico molecular docking against TNFα, TGFBR1, and IL-1β showed that some of the molecules identified in ZFE can bind to the three wound-healing related protein actives sites. Additionally, PASS computational calculation of antioxidant activity revealed potential activity of three phenolic compounds (Pa score > 0.5). Consequently, ZFE may be a potential alternative medication helping wound healing owing to its antioxidant and anti-inflammatory activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.