Evidence map›Paper›PMID 35684151›Full record

ArticleNutrients2022

Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies.

Nathalie Rohmann, Liasita Munthe, Kristina Schlicht, Corinna Geisler, Tobias J Demetrowitsch, Corinna Bang, Julia Jensen-Kroll, Kathrin Türk, Petra Bacher, Andre Franke and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Nathalie RohmannInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Liasita MuntheInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Kristina SchlichtInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Corinna GeislerInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.ORCID 0000-0002-2383-3596
Tobias J DemetrowitschDivision of Food Technology, Department of Human Nutrition, Kiel University, 24105 Kiel, Germany.
Corinna BangInstitute of Clinical Molecular Biology, Kiel University, 24105 Kiel, Germany.
Julia Jensen-KrollDivision of Food Technology, Department of Human Nutrition, Kiel University, 24105 Kiel, Germany.
Kathrin TürkInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Petra BacherInstitute of Clinical Molecular Biology, Kiel University, 24105 Kiel, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Kiel University, 24105 Kiel, Germany.
Karin SchwarzDivision of Food Technology, Department of Human Nutrition, Kiel University, 24105 Kiel, Germany.ORCID 0000-0002-3943-0564
Dominik M SchulteInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.ORCID 0000-0002-4622-6051
Matthias LaudesInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Clinical Research Center Kiel · DEChristian-Albrechts-Universität zu Kiel · DE

Funding

Federal Ministry of Education and Research 0315539AFederal Ministry of Food and Agriculture 2816ERA14E
6 · The paper itself

Abstract

backgroundAlongside metabolic diseases (esp. obesity), allergic disorders are becoming increasingly prevalent. Since both obesity and allergies are highly impacted by environmental determinants, with this study we assessed the potential link between metabolic implications and two distinct types of allergies.

methodsUsing cross-sectional data from the German FoCus cohort,

resultsObesity and metabolic alterations were found significantly more prevalent in subjects with allergies. In fact, this relation was more pronounced in contact allergy than hay fever. Subsequent BMI-adjusted analysis reveals particular importance of co-occurring hyperlipidaemia for both allergy types. For contact allergy, we revealed a strong association to the dietary intake of poly-unsaturated fatty acids, particularly α-linolenic acid, as well as the enrichment of the corresponding metabolic pathway. For hay fever, there were no major associations to the diet but to a lower physical activity level, shorter duration of sleep, and an altered gut microbial composition. Finally, genetic predisposition for hyperlipidaemia was associated to both contact allergy and hay fever.

conclusionsReflected by higher allergy prevalence, our findings indicate an impaired immune response in obesity and hyperlipidaemia, which is differentially regulated in type I and type IV allergies by an unfavourable lifestyle constellation and subsequent microbial and metabolic dysfunctions.

Indexed as

HyperlipidemiasHypersensitivityHypersensitivity, DelayedRhinitis, Allergic, SeasonalCross-Sectional StudiesEatingHumansObesitySedentary Behaviorallergydiet and lifestylehyperlipidaemiaobesity

Identifiers

PMID35684151
PMCPMC9182605
OpenAlexW4281924926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.