Evidence map›Paper›PMID 35684145›Full record

ReviewNutrients2022

Dietary and Nutrient Patterns and Brain MRI Biomarkers in Dementia-Free Adults.

Archontoula Drouka, Eirini Mamalaki, Efstratios Karavasilis, Nikolaos Scarmeas, Mary Yannakoulia

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. MIND diet, cerebrovascular health, and cognition among community-dwelling older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Diets to promote healthy brain ageing.Nature reviews. Neurology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Dairy products and brain structure in French older adults.The British journal of nutrition · 2024
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Archontoula DroukaDepartment of Nutrition and Dietetics, Harokopio University, 176 71 Athens, Greece.
Eirini MamalakiDepartment of Nutrition and Dietetics, Harokopio University, 176 71 Athens, Greece.
Efstratios KaravasilisSchool of Medicine, Democritus University of Thrace, 68100 Alexandroupoli, Greece.ORCID 0000-0002-7291-2231
Nikolaos Scarmeas1st Department of Neurology, Medical School, National and Kapodistrian University of Athens, Aeginition University Hospital, 115 28 Athens, Greece.
Mary YannakouliaDepartment of Nutrition and Dietetics, Harokopio University, 176 71 Athens, Greece.ORCID 0000-0003-2171-7337
Harokopio University of Athens · GRDemocritus University of Thrace · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive impairment is a rapidly growing public health problem. As there is no curative treatment for dementia, the proactive management of modifiable risk factors and the identification of early biomarkers indicative of the cognitive decline are of great importance. Although nutrition is one of the most extensively studied lifestyle factor in relation to cognitive health, its association with brain magnetic resonance imaging (MRI) biomarkers is not well established. In the present work, we review available studies relating dietary or nutrient patterns with brain MRI biomarkers in dementia-free adults. Greater adherence to the Mediterranean diet has been associated with the preservation of structural connectivity and less brain atrophy in adults without dementia. In addition, specific nutrient patterns, characterized by a high intake of antioxidant vitamins, polyphenols and unsaturated fatty acids, have been related to larger brain volume. Although the results are encouraging regarding the role of dietary and nutrient patterns on imaging biomarkers, more well-designed observational longitudinal studies and clinical trials are needed in order to confirm potentially causal relationships and better understand underlying mechanisms.

Indexed as

Cognitive DysfunctionDementiaDiet, MediterraneanAdultBiomarkersBrainHumansMagnetic Resonance ImagingVitaminsBiomarkersVitaminsbrain imaging biomarkersbrain MRIcognitive healthdementiadietary patterns

Identifiers

PMID35684145
PMCPMC9183163
OpenAlexW4281954232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.