ArticleNutrients2022
The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Childhood trauma and physical activity link immunometabolic biomarkers and psychiatric symptoms in medically healthy adults.Acta neuropsychiatrica · 2026Article
- HALP, a routine nutrition-inflammation index, and mortality across the cMetS spectrum: NHANES with supportive external cohort evidence.Frontiers in nutrition · 2026Article
- Article
- Dietary and health risk behaviors for metabolic diseases in different age groups: a cross-sectional study in Chongqing, China.BMC public health · 2025Article
- Heterogeneity and associated factors of patients with polycystic ovary syndrome health behaviors: a latent class analysis.BMC endocrine disorders · 2023Article
- Association of coffee consumption pattern and metabolic syndrome among middle-aged and older adults: A cross-sectional study.Frontiers in public health · 2023Article
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Authors and funding
9 authors.
Funding
Abstract
Chronic diseases develop via complex pathways, depending on the degree of exposure to risk factors from early in life and childhood onward. Metabolic syndrome has multiple risk factors, including genetic factors, inappropriate diet, and insufficient physical activity. This study classified health-related behavior classes in childhood and adolescents and analyzed the direct and indirect effects of each class on the metabolic risk in inflammation-mediated pathways. We identified the health-related lifestyle classes based on health-related behavior indicators in subjects aged 3-15 years who participated in the Ewha Birth and Growth Cohort Study by using a latent class analysis. A mediation analysis was performed to access the direct and indirect effects of each class on the continuous metabolic syndrome score (cMetS), with the inflammatory index used as a mediating factor. Subjects were classified into inactive and positive lifestyle classes according to their characteristics. In the inactive lifestyle class, interleukin (IL)-6 and cMetS had a significant association. The study confirmed that IL-6 exerts a significant indirect effect between inactive lifestyle and cMetS. This result supports previous studies. Since the health behaviors of children and adolescents can affect the likelihood of subsequent metabolic syndrome, appropriate health behavior interventions for this period are needed.
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