ReviewNutrients2022
Effect of Early Nutritional Support on Clinical Outcomes of Critically Ill Patients with Sepsis and Septic Shock: A Single-Center Retrospective Study.
Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Mortality among adult patients with sepsis and septic shock in Korea: a systematic review and meta-analysis.Clinical and experimental emergency medicine · 2023Pooled it
- Nutritional Status-Based Model for Predicting Low-Lactate Shock: A Retrospective Cohort Study.Shock (Augusta, Ga.) · 2026Article
- Advances and Challenges in Obstetric Intensive Care Medicine.Journal of clinical medicine · 2026Review
- Association between initial diastolic arterial pressure and gastrointestinal dysfunction during the first ICU week in septic shock patients.Scientific reports · 2026Observational
- Relationship of the Endothelial Activation and Stress Index with 28-day mortality in urosepsis patients: a retrospective two-cohort investigation.Frontiers in medicine · 2026Article
- Association between serum 25-hydroxyvitamin D, nutritional status, and inflammatory markers in sepsis patients with and without sarcopenia.Frontiers in medicine · 2026Article
- Gut microbiota and sepsis: mechanisms, clinical correlations, and therapeutic prospects.Frontiers in medicine · 2026Article
- Red cell distribution width to albumin ratio predicts short-term mortality in urosepsis: a dual-cohort study.Frontiers in nutrition · 2026Article
- Effect of dietitian-guided nutritional support on intensive care units length of stay and nutritional risk in critically Ill patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026Article
- Development and evaluation of a machine learning-based risk prediction model for enteral feeding intolerance in sepsis patients.Frontiers in nutrition · 2026Article
- Early versus delayed enteral nutrition in septic shock: a target trial emulation study.Frontiers in nutrition · 2026Article
- Nutritional Risk and 30-Day In-Hospital Mortality in Adults With Sepsis and Septic Shock: A Retrospective Cohort Study.Journal of nursing management · 2026Article
- The red cell distribution width to albumin ratio as a novel biomarker for predicting short-term mortality in severe pulmonary sepsis: a retrospective study with dual-cohort validation.Frontiers in medicine · 2026Article
- The impact of early nutritional support on in-hospital mortality in patients with sepsis caused by bacterial or viral infections: a retrospective cohort study.European journal of medical research · 2025Article
- Association between protein and energy intake during acute phase and sepsis outcomes: a retrospective cohort study.Scientific reports · 2025Article
- Association between early enteral nutrition and 28-Day mortality in mechanically ventilated patients with sepsis: a retrospective analysis of the MIMIC-IV database.BMC infectious diseases · 2025Observational
- Large Language Model-Driven Knowledge Graph Construction in Sepsis Care Using Multicenter Clinical Databases: Development and Usability Study.Journal of medical Internet research · 2025Article
- Article
- L-shaped association of body mass index with prognosis in individuals with sepsis: a multicenter cohort study.Diabetology & metabolic syndrome · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The initial nutritional delivery policy for patients with sepsis admitted to the intensive care unit (ICU) has not been fully elucidated. We aimed to determine whether an initial adequate nutrition supply and route of nutrition delivery during the first week of sepsis onset improve clinical outcomes of critically ill patients with sepsis. We reviewed adult patients with sepsis and septic shock in the ICU in a single tertiary teaching hospital between 31 November 2013 and 20 May 2017. Poisson log-linear and Cox regressions were performed to assess the relationships between clinical outcomes and sex, modified nutrition risk in the critically ill score, sequential organ failure assessment score, route of nutrition delivery, acute physiology and chronic health evaluation score, and daily energy and protein delivery during the first week of sepsis onset. In total, 834 patients were included. Patients who had a higher protein intake during the first week of sepsis onset had a lower in-hospital mortality (adjusted hazard ratio (HR), 0.55; 95% confidence interval (CI), 0.39−0.78; p = 0.001). A higher energy intake was associated with a lower 30-day mortality (adjusted HR, 0.94; 95% CI, 0.90−0.98; p = 0.003). The route of nutrition delivery was not associated with 1-year mortality in the group which was underfed; however, in patients who met > 70% of their nutritional requirement, enteral feeding (EN) with supplemental parenteral nutrition (PN) was superior to only EN (p = 0.016) or PN (p = 0.042). In patients with sepsis and septic shock, a high daily average protein intake may lower in-hospital mortality, and a high energy intake may lower the 30-day mortality, especially in those with a high modified nutrition risk in the critically ill scores. In patients who receive adequate energy, EN with supplemental PN may be better than only EN or PN, but not in underfed patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.