Evidence map›Paper›PMID 35684101›Full record

SynthesisNutrients2022

A Systematic Review of Vitamin D during Pregnancy and Postnatally and Symptoms of Depression in the Antenatal and Postpartum Period from Randomized Controlled Trials and Observational Studies.

Jacqueline F Gould, Robert A Gibson, Tim J Green, Maria Makrides

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jacqueline F GouldSAHMRI Women and Kids, South Australian Health and Medical Research Institute, 72 King William Road, North Adelaide, SA 5006, School of Psychology and the Discipline of Paediatrics, Faculty of Health and Medical Sciences, The University of Adelaide, North Terrace, Adelaide, SA 5000, Australia.
Robert A GibsonSchool of Agriculture, Food and Wine, The University of Adelaide, North Terrace, Adelaide, SA 5000, SAHMRI Women and Kids, South Australian Health and Medical Research Institute, 72 King William Road, North Adelaide, SA 5006, Australia.
Tim J GreenSAHMRI Women and Kids, South Australian Health and Medical Research Institute, 72 King William Road, North Adelaide, SA 5006, School of Medicine, Faculty of Health and Medical Sciences, The University of Adelaide, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0002-0667-4300
Maria MakridesSAHMRI Women and Kids, South Australian Health and Medical Research Institute, 72 King William Road, North Adelaide, SA 5006, School of Medicine, Discipline of Paediatrics, Faculty of Health and Medical Sciences, The University of Adelaide, North Terrace, Adelaide, SA 5000, Australia.ORCID 0000-0003-3832-541X
South Australian Health and Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is a common mood disorder associated with childbirth and is hypothesized to be affected by low vitamin D. This systematic review identified two randomized controlled trials (RCT) of vitamin D supplementation for the treatment or prevention of depressive symptoms in the perinatal period, as well as 18 observational studies of vitamin D exposure and depression in the antenatal and postnatal periods. Both RCTs claimed an improvement in depressive symptoms in the vitamin D group, although the sample sizes were too small to draw firm conclusions. The case-control and cohort studies had mixed findings and were limited by study quality. There were inconsistent results within the few studies with a more robust methodology or within samples restricted to women likely to have depression. The current evidence is inconclusive due to the poor quality and heterogeneity of studies, likely contributing to the contradictory findings. Given there are already numerous RCTs of prenatal vitamin D supplementation, we recommend adding an appropriate measure of depression in the perinatal period to assist in resolving the uncertainty.

Indexed as

DepressionVitamin DDietary SupplementsFemaleHumansPostpartum PeriodPregnancyRandomized Controlled Trials as TopicVitaminsVitamin DVitaminsdepressionpostpartumpregnancysupplementationsystematic reviewvitamin Dvitamin D deficiency

Identifiers

PMID35684101
PMCPMC9183028
OpenAlexW4281862650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.