ArticleNutrients2022
Hyperuricemia and Its Association with Osteoporosis in a Large Asian Cohort.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 23 citations in OpenAlex.
- A Novel Approach to Determining Bone Loss Through Serum Uric Acid Levels: A Retrospective Multicenter Cohort Analysis.Journal of clinical medicine · 2026Article
- Association Between Metabolic Syndrome and Psychiatric Morbidity in a Nationwide Taiwanese Population Study.Nutrients · 2026Article
- Exploration of purine metabolism-related genes in the development of osteoporosis by integrated analyses and experiments.European journal of medical research · 2025Article
- Environmental Lead Exposure Predicts Lower Bone Mineral Density in a Large Taiwanese Population-Based Study.International journal of medical sciences · 2025Article
- Metabolic syndrome is associated with gastroesophageal reflux disease in a large Taiwanese population study.International journal of medical sciences · 2025Article
- Metformin improves HPRT1-targeted purine metabolism and repairs NR4A1-mediated autophagic flux by modulating FoxO1 nucleocytoplasmic shuttling to treat postmenopausal osteoporosis.Cell death & disease · 2024Article
- Vegetarian Diet Reduced Gastroesophageal Reflux Disease in a Nationwide Longitudinal Survey in Taiwan.Nutrients · 2024Article
- The association between triglyceride glucose index and gout: a cross-sectional analysis based on NHANES 2007-2018.BMC endocrine disorders · 2024Article
- Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial.Heliyon · 2024Article
- The association between body mass index and osteoporosis in a Taiwanese population: a cross-sectional and longitudinal study.Scientific reports · 2024Article
- Secondhand smoke increases the risk of developing chronic obstructive pulmonary disease.Scientific reports · 2024Article
- Article
- The impact of secondhand smoke on the development of kidney stone disease is not inferior to that of smoking: a longitudinal cohort study.BMC public health · 2023Article
- Association between Serum Uric Acid Levels and Bone Mineral Density in Taiwanese Elderly Population.International journal of environmental research and public health · 2023Article
- Association between serum uric acid level and bone mineral density in men more than 50 years of age.Frontiers in endocrinology · 2023Observational
- Association between serum uric acid levels and atrial fibrillation in different fasting glucose patterns: A case-control study.Frontiers in endocrinology · 2023Article
- Living alone is associated with a higher prevalence of psychiatric morbidity in a population-based cross-sectional study.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we aimed to examine the protective role of hyperuricemia in the prevalence of osteoporosis in a large Asian cohort. A total of 119,037 participants from 29 recruitment centers in Taiwan were enrolled onto our study. Participants with serum uric acid greater than 7.0 mg/dL in men and 6.0 mg/dL in women were classified as the hyperuricemia group whereas the others were the control group. The mean age of all participants was 50; there were 23,114 subjects (19%) with hyperuricemia. Osteoporosis was observed in 8243 (9%) and 1871 (8%) participants in the control and hyperuricemia groups, respectively. After adjusting for confounders, a lower risk of osteoporosis was found in the hyperuricemia group compared with the control group (odds ratio, 0.916; 95% confidence interval, 0.864 to 0.970). A subgroup analysis showed that hyperuricemia was associated with a lower risk of osteoporosis in females, but not in males. Women with serum uric acid greater than 8.0 mg/dL were not associated with a greater risk of osteoporosis. Our study suggests that hyperuricemia decreases the risk of osteoporosis in females, but not in males. The protective role was no longer apparent when the serum uric acid level was greater than 8 mg/dL.
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