Incorporation of Glutamic Acid or Amino-Protected Glutamic Acid into Poly(Glycerol Sebacate): Synthesis and Characterization.

Yi-Sheng Jiang, Ming-Hsien Hu, Jeng-Shiung Jan, Jin-Jia Hu

Abstract read

In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yi-Sheng JiangDepartment of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.

Ming-Hsien HuBachelor Program for Design and Materials for Medical Equipment and Devices, Da-Yeh University, Changhua 515, Taiwan.

Jeng-Shiung JanDepartment of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0002-8379-404X

Jin-Jia HuDepartment of Mechanical Engineering, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0002-1781-6378

Funding

Ministry of Science and Technology MOST 110-2221-E-A49 -015National Health Research Institutes NHRI-EX110-10827EI

6 · The paper itself

Abstract

Poly(glycerol sebacate) (PGS), a soft, tough elastomer with excellent biocompatibility, has been exploited successfully in many tissue engineering applications. Although tunable to some extent, the rapid in vivo degradation kinetics of PGS is not compatible with the healing rate of some tissues. The incorporation of L-glutamic acid into a PGS network with an aim to retard the degradation rate of PGS through the formation of peptide bonds was conducted in this study. A series of poly(glycerol sebacate glutamate) (PGSE) containing various molar ratios of sebacic acid/L-glutamic acid were synthesized. Two kinds of amino-protected glutamic acids, Boc-L-glutamic acid and Z-L-glutamic acid were used to prepare controls that consist of no peptide bonds, denoted as PGSE-B and PGSE-Z, respectively. The prepolymers were characterized using

Indexed as

elastomerlipasepi stackingpoly(ester amide)poly(glycerol sebacate)soft tissue engineeringπ-π stacking interactions

Identifiers

PMID35683879

DOI10.3390/polym14112206

PMCPMC9182726

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.