Evidence map›Paper›PMID 35683869›Full record

ArticlePolymers2022

Cryo-Structuring of Polymeric Systems. Poly(Vinyl Alcohol)-Based Cryogels Loaded with the Poly(3-hydroxybutyrate) Microbeads and the Evaluation of Such Composites as the Delivery Vehicles for Simvastatin.

Dmitrii A Michurov, Tatiana K Makhina, Valentina Siracusa, Anton P Bonartsev, Vladimir I Lozinsky, Alexey L Iordanskii

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Dmitrii A MichurovA.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov Street, 28, 119991 Moscow, Russia.
Tatiana K MakhinaResearch Center of Biotechnology of the Russian Academy of Sciences, 33, Bld. 2 Leninskiy Ave., 119071 Moscow, Russia.
Valentina SiracusaDepartment of Chemical Science (DSC), University of Catania, Viale A. Doria 6, 95125 Catania, Italy.ORCID 0000-0001-9055-5082
Anton P BonartsevFaculty of Biology, M.V. Lomonosov Moscow State University, 119234 Moscow, Russia.
Vladimir I LozinskyA.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov Street, 28, 119991 Moscow, Russia.
Alexey L IordanskiiN.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Kosygin Street, 4, 119991 Moscow, Russia.ORCID 0000-0003-0771-0825
Lomonosov Moscow State University · RUA. N. Nesmeyanov Institute of Organoelement Compounds · RURussian Academy of Sciences · RUSemenov Institute of Chemical Physics · RUUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highly porous composite poly(vinyl alcohol) (PVA) cryogels loaded with the poly(3-hydroxybutyrate) (PHB) microbeads containing the drug, simvastatin (SVN), were prepared via cryogenic processing (freezing-storing frozen-defrosting) of the beads' suspensions in aqueous PVA solution. The rigidity of the resultant composite cryogels increased with increasing the filler content. Optical microscopy of the thin section of such gel matrices revealed macro-porous morphology of both continuous (PVA cryogels) and discrete (PHB-microbeads) phases. Kinetic studies of the SVN release from the drug-loaded microbeads, the non-filled PVA cryogel and the composite material showed that the cryogel-based composite system could potentially serve as a candidate for the long-term therapeutic system for controlled drug delivery. Such PHB-microbeads-containing PVA-cryogel-based composite drug delivery carriers were unknown earlier; their preparation and studies have been performed for the first time.

Indexed as

composite cryogelsdrug releasemicrostructurephysico-mechanical propertiespoly(3-hydroxybutyrate)poly(vinyl alcohol)simvastatin

Identifiers

PMID35683869
PMCPMC9182817
OpenAlexW4281781782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.