Evidence map›Paper›PMID 35683861›Full record

ReviewPolymers2022

Functional Ultra-High Molecular Weight Polyethylene Composites for Ligament Reconstructions and Their Targeted Applications in the Restoration of the Anterior Cruciate Ligament.

Sonia B Wahed, Colin R Dunstan, Philip A Boughton, Andrew J Ruys, Shaikh N Faisal, Tania B Wahed, Bidita Salahuddin, Xinying Cheng, Yang Zhou, Chun H Wang and 2 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. [Applications and challenges of ultra-high molecular weight polyethylene fibers in minimally invasive medical devices].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Sonia B WahedSchool of Biomedical Engineering, University of Sydney, Sydney, NSW 2006, Australia.
Colin R DunstanSchool of Biomedical Engineering, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0001-7586-4071
Philip A BoughtonSchool of Biomedical Engineering, University of Sydney, Sydney, NSW 2006, Australia.
Andrew J RuysSchool of Biomedical Engineering, University of Sydney, Sydney, NSW 2006, Australia.
Shaikh N FaisalARC Centre of Excellence for Electromaterials Science & Intelligent Polymer Research Institute, Australian Institute of Innovative Materials, University of Wollongong, Wollongong, NSW 2522, Australia.
Tania B WahedDepartment of Pharmacy, Jahangirnagar University, Savar 1342, Bangladesh.
Bidita SalahuddinSchool of Chemical Engineering, The University of Queensland, Brisbane, QLD 4072, Australia.
Xinying ChengSchool of Biomedical Engineering, University of Sydney, Sydney, NSW 2006, Australia.
Yang ZhouSchool of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
Chun H WangSchool of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
Mohammad S IslamSchool of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
Shazed AzizSchool of Chemical Engineering, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-8834-0397
The University of Sydney · AUUNSW Sydney · AUThe University of Queensland · AUJahangirnagar University · BDUniversity of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The selection of biomaterials as biomedical implants is a significant challenge. Ultra-high molecular weight polyethylene (UHMWPE) and composites of such kind have been extensively used in medical implants, notably in the bearings of the hip, knee, and other joint prostheses, owing to its biocompatibility and high wear resistance. For the Anterior Cruciate Ligament (ACL) graft, synthetic UHMWPE is an ideal candidate due to its biocompatibility and extremely high tensile strength. However, significant problems are observed in UHMWPE based implants, such as wear debris and oxidative degradation. To resolve the issue of wear and to enhance the life of UHMWPE as an implant, in recent years, this field has witnessed numerous innovative methodologies such as biofunctionalization or high temperature melting of UHMWPE to enhance its toughness and strength. The surface functionalization/modification/treatment of UHMWPE is very challenging as it requires optimizing many variables, such as surface tension and wettability, active functional groups on the surface, irradiation, and protein immobilization to successfully improve the mechanical properties of UHMWPE and reduce or eliminate the wear or osteolysis of the UHMWPE implant. Despite these difficulties, several surface roughening, functionalization, and irradiation processing technologies have been developed and applied in the recent past. The basic research and direct industrial applications of such material improvement technology are very significant, as evidenced by the significant number of published papers and patents. However, the available literature on research methodology and techniques related to material property enhancement and protection from wear of UHMWPE is disseminated, and there is a lack of a comprehensive source for the research community to access information on the subject matter. Here we provide an overview of recent developments and core challenges in the surface modification/functionalization/irradiation of UHMWPE and apply these findings to the case study of UHMWPE for ACL repair.

Indexed as

biofunctionalizationligamentsurface modificationsynthetic grafttendonultra-high molecular weight polyethylene

Identifiers

PMID35683861
PMCPMC9182730
OpenAlexW4281805913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.