ReviewPolymers2022
Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering.
Review in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- In Situ Fabrication of Bacterial Cellulose-Polyhydroxyalkanoate Composite Membranes from Coconut Water: Mechanical Performance and Life Cycle Assessment.Gels (Basel, Switzerland) · 2026Article
- Systematic Evaluation of Structure-Property-Biocompatibility Relationships of Polyhydroxyalkanoate Copolymers for Advanced Veterinary Applications.Molecules (Basel, Switzerland) · 2026Article
- Tenebrio molitor-Derived Enzyme Systems Enable Solvent-Reduced Recovery of Intracellular Polyhydroxyalkanoates.Microbial biotechnology · 2026Article
- Article
- Parameter Optimisation in 3D Extrusion Printing of Polyhydroxybutyrate Using Design of Experiment Methodology.Journal of functional biomaterials · 2026Article
- Tracking the Progress of Biocomposites Based on Poly(3-hydroxybutyrate) with Hypromellose Additives via Thermal Analysis, Mechanical Properties, and Biological Studies.International journal of molecular sciences · 2026Article
- Photovoltaic Microorganism Hybrid Systems for Enhanced Polyhydroxybutyrate Synthesis Through Material Design and Energy Mass Transfer Mechanisms.Materials (Basel, Switzerland) · 2025Review
- Bio-Based Composites with Encapsulated Phase Change Materials for Sustainable Thermal Energy Storage: A Review.Polymers · 2025Review
- Impact of Polymer Degradation on Cellular Behavior in Tissue Engineering.Bioprinting (Amsterdam, Netherlands) · 2025Article
- Biodegradable Polyesters: Approaches to Increase Degradation Rates for Biomedical Applications.ACS macro letters · 2025Review
- A biodegradable, microstructured, electroconductive and nano-integrated drug eluting patch (MENDEP) for myocardial tissue engineering.Bioactive materials · 2025Article
- Review
- Synthesis and use of thermoplastic polymers for tissue engineering purposes.International journal of pharmaceutics: X · 2025Review
- Cell Sizes Matter for Industrial Bioproduction, a Case of Polyhydroxybutyrate.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Innovative spiral nerve conduits: Addressing nutrient transport and cellular activity for critical-sized nerve defects.Bioactive materials · 2025Article
- Materials designed to degrade: structure, properties, processing, and performance relationships in polyhydroxyalkanoate biopolymers.Polymer chemistry · 2025Review
- Demonstration of bioplastic production from CO2 and formate using the reductive glycine pathway in E. coli.PloS one · 2025Article
- Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications.Advanced healthcare materials · 2024Review
- Structural and Thermal Characterization of BluephaMaterials (Basel, Switzerland) · 2024Article
- Enhancing the Potential of PHAs in Tissue Engineering Applications: A Review of Chemical Modification Methods.Materials (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Tissue engineering technology aids in the regeneration of new tissue to replace damaged or wounded tissue. Three-dimensional biodegradable and porous scaffolds are often utilized in this area to mimic the structure and function of the extracellular matrix. Scaffold material and design are significant areas of biomaterial research and the most favorable material for seeding of in vitro and in vivo cells. Polyhydroxyalkanoates (PHAs) are biopolyesters (thermoplastic) that are appropriate for this application due to their biodegradability, thermo-processability, enhanced biocompatibility, mechanical properties, non-toxicity, and environmental origin. Additionally, they offer enormous potential for modification through biological, chemical and physical alteration, including blending with various other materials. PHAs are produced by bacterial fermentation under nutrient-limiting circumstances and have been reported to offer new perspectives for devices in biological applications. The present review discusses PHAs in the applications of conventional medical devices, especially for soft tissue (sutures, wound dressings, cardiac patches and blood vessels) and hard tissue (bone and cartilage scaffolds) regeneration applications. The paper also addresses a recent advance highlighting the usage of PHAs in implantable devices, such as heart valves, stents, nerve guidance conduits and nanoparticles, including drug delivery. This review summarizes the in vivo and in vitro biodegradability of PHAs and conducts an overview of current scientific research and achievements in the development of PHAs in the biomedical sector. In the future, PHAs may replace synthetic plastics as the material of choice for medical researchers and practitioners.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.