ReviewJournal of clinical medicine2022
Hypercapnia in COPD: Causes, Consequences, and Therapy.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- The safety and efficacy of nocturnal noninvasive positive pressure ventilation in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Efficacy and safety of medroxyprogesterone acetate on noninvasive ventilation -treated exacerbated COPD patients: a double-blind randomized clinical trial.BMC pulmonary medicine · 2025Trial
- Comparing effects of breathing exercises alone and combined with breathing-stretching exercises on respiratory indices, disease severity and exercise capacity in COPD.Scientific reports · 2025Trial
- Chronic Hypercapnic Respiratory Failure in COPD in Lithuania: National Registry Trends and Prehospital Emergency-Care Professionals' Knowledge of Hypercapnia and Oxygen Therapy.Diagnostics (Basel, Switzerland) · 2026Article
- Inflammatory Prognostic Markers in COPD: Clinical Utility of CAR and MGPS.Journal of clinical medicine · 2026Article
- Effects of Permissive Hypercapnia During Lung Surgery on Inflammatory Biomarkers in Serum and Bronchoalveolar Lavage Fluid: A Randomized Controlled Trial.Metabolites · 2026Article
- The safety and efficacy of lung volume reduction surgery: A 25-year single institution experience.JTCVS open · 2026Article
- An interpretable prognostic model for early unfavorable outcomes after bronchiectasis surgery.BMC pulmonary medicine · 2026Article
- Prognostic Value of the TAPSE/sPAP Ratio in Patients with Type 2 Respiratory Failure: Insights into Right Ventricular-Pulmonary Arterial Coupling and Clinical Outcomes.Diagnostics (Basel, Switzerland) · 2026Article
- Hypercapnia at admission, regardless of acidosis, may worsen the outcome of hospitalised patients with chronic obstructive pulmonary disease exacerbations.Internal and emergency medicine · 2026Article
- Delayed Emergence Due to Severe Respiratory Acidosis Following Prolonged Spine Surgery: A Case Report.Cureus · 2026Article
- Interpreting peripheral oxygen saturation variability in critical illness: A directional framework adjusted for hypoxia severity.Experimental physiology · 2026Article
- Precision Oxygen Therapy in the Intensive Care Unit: Matching Oxygen Exposure to Patient Phenotypes.Journal of personalized medicine · 2026Article
- Review
- Associations Between Albumin-Corrected Anion Gap and Mortality in Heart Failure Patients with Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2026Article
- The Association Between Stomach Disease and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Analysis of the 2018 China Health and Retirement Longitudinal Study (CHARLS).International journal of chronic obstructive pulmonary disease · 2026Article
- Chronic lung diseases and kidney disease: pathophysiology and management.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- The Association Between the Eosinophilic COPD Phenotype with Overall Survival and Exacerbations in Patients on Long-Term Non-Invasive Ventilation.Biomolecules · 2025Article
- The ADVanced Organ Support (ADVOS) hemodialysis system balances blood pH within 24 h in patients with multiple organ failure and hypercapnic acidosis.Intensive care medicine experimental · 2025Article
- Differential diagnosis of chronic obstructive pulmonary disease and obesity hypoventilation syndrome in patients presenting with hypercapnic respiratory failure.Sleep & breathing = Schlaf & Atmung · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder that may lead to gas exchange abnormalities, including hypercapnia. Chronic hypercapnia is an independent risk factor of mortality in COPD, leading to epithelial dysfunction and impaired lung immunity. Moreover, chronic hypercapnia affects the cardiovascular physiology, increases the risk of cardiovascular morbidity and mortality, and promotes muscle wasting and musculoskeletal abnormalities. Noninvasive ventilation is a widely used technique to remove carbon dioxide, and several studies have investigated its role in COPD. In the present review, we aim to summarize the causes and effects of chronic hypercapnia in COPD. Furthermore, we discuss the use of domiciliary noninvasive ventilation as a treatment option for hypercapnia while highlighting the controversies within the evidence. Finally, we provide some insightful clinical recommendations and draw attention to possible future research areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.